한국 여성 노인에서 α-Adducin, Angiotensinogen, ACE 유전자다형성 및 나트륨 섭취수준에 따른 혈압의 비교

다국어 초록 (Multilingual Abstract)

Gene polymorphisms that are associated with sodium homeostasis in the body, such as α-adducin (ADD1, Gly460Trp), angiotensinogen (AGT, Met235Thr), and angiotensin converting enzyme (ACE, Ins/Del) may increase the risk for the development of hypertension. The purpose of this study was to elucidate the relationship between the singular and combined effects of ADD1, AGT, ACE genotypes, and blood pressure in elderly population. Moreover, we examined the interaction of sodium intake and polymorphisms of aforementioned genes and their effects on blood pressure. Among one hundred and nine female subjects, aged 60 and over (mean 75.9 yr), the major alleles for ADD1, AGT, and ACE polymorphisms in the studied population were Gly (66.1%), Thr (64.2%), Ins (83.5%), respectively. Analysis on the combined effects of genetic variation showed that subjects who were both ADD1 Trp/Trp and ACE Del/Del homozygotes had significantly higher systolic blood pressure (p=0.01). Similarly, ACE Del/Del homozygotes who had AGT Met allele had significantly higher diastolic blood pressure (p＜0.001). However, in single-gene analyses, no association was found between any specific genotype and blood pressure. In subjects with low sodium intake, ADD1 Trp/Trp homozygotes had significantly higher systolic blood pressure than subjects who had ADD1 Gly allele (138 mmHg vs. 127 mmHg, p=0.03). There was no difference in blood pressure between ADD1 Trp/Trp and ADD1 Gly/Gly or Gly/Trp, in subjects with high sodium intake. In summary, this study shows that interactions between the ADD1, AGT and ACE genes influence systolic and diastolic blood pressure in elderly subjects, and dietary sodium intake can modulate the effects of ADD1 Gly460Trp polymorphisms on systolic blood pressure.

목차 (Table of Contents)

• Abstract
• 서론
• 대상 및 방법
• 결과 및 고찰
• 요약
• 감사의 글
• 문헌

참고문헌 (Reference)

1 "Variation in the region of the angiotensin-converting enzyme gene influences interindividual differences in blood pressure levels in young white males" 97 : 1773-1779, 1998

2 "Variation at the angiotensin-converting enzyme gene and angiotensinogen gene loci in relation to blood pressure" 28 : 1070-1075, 1996

3 "Variation at the M235T locus of the angiotensinogen gene and essential hypertension: a population-based case-control study from Rochester, Minnesota." 96 : 295-300, 1995

4 "The serum angiotensinogen concentration and variants of the angiotensinogen gene in white and black children" 95 : 948-953, 1995

5 "The role of alpha-ADD1 polymorphism in blood pressure and sodium handling regulation may not be excluded by a negative association study." 34 : 649-654, 1999

6 "The causes of death statistics in 2005" Korea National Statistical Office 2006

7 "The angiotensinogen T235 variant and the use of antihypertensive drugs in a population-based cohort" 29 : 628-633, 1997

8 "The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report." 289 : 2560-2572, 2003

9 "Salt usage behaviors are related to urinary sodium excretion in normotensive Korean adults" 2007

10 "Reassessment of anthropometric indices of obesity" Asian BMI/obesity workshop meeting, 1999

11 "Polymorphisms of alpha-ADD1 and salt sensitivity in patients with essential hypertension" 349 : 1353-1357, 1997

12 "Polymophism at the AGT and angiotensin II type 1 receptor loci and normal blood pressure" 53 : 214-219, 1998

13 "Mechanism of the blood pressure and renal hemodynamic effects of captopril" 49 : 1527-1529, 1982

14 "M235T angiotensinogen gene polymorphism and cardiovascular renal risk" 17 : 9-17, 1999

15 "Low-renin hypertension, altered sodium homeostasis, and an alpha-ADD1 polymorphism" 39 : 191-196, 2002

16 "Implications of small reductions in diastolic blood pressure for primary prevention" 155 : 701-709, 1995

17 "Haplotypes of angiotensinogen in essential hypertension" 60 : 1448-1460, 1997

18 "Evidence for association and genetic linkage of the angiotensin-converting enzyme locus with hypertension and blood pressure in men but not women in the Framingham Heart Study" 97 : 1766-1772, 1998

19 "End-stage renal disease in African- American and white men" 16 1293-277 1298, 1997

20 "Effects of three candidate genes on prevalence and incidence of hypertension in a Caucasian population" 19 : 1349-1358, 2001

21 "Effects of ACE I/D and AT1R-A1166C polymorphisms on blood pressure in a healthy normotensive primary care population: first results of the Hippocates study" 21 : 81-86, 2003

22 "Dietary salt and blood pressure" 676 : 122-156, 1993

23 "Deletion allele of angiotensin-converting enzyme gene increases risk of essential hypertension in Japanese men: the Suita Study." 101 : 2060-2065, 2000

24 "Blood pressure in relation to three candidate genes in a Chinese population" 22 : 937-944, 2004

25 "Blood pressure and the M235T polymorphism of the angiotensinogen gene" 28 : 907-911, 1996

26 "Associations of candidate loci angiotensinogen and angiotensin-converting enzyme with severe hypertension: The NHLBI Family Heart Study." 7 : 13-21, 1997

27 "Association of ACE I/D polymorphism with cardiovascular risk factors" 107 : 239-242, 2000

28 "Association between the angiotensinogen 235T-variant and essential hypertension in whites: a systematic review and methodological appraisal." 30 : 1331-1337, 1997

29 "Angiotensinogen gene in human hypertension Lack of an association of the 235T allele among African Americans" 591-24 594, 1994

30 "Angiotensinogen gene and blood pressure in the Japanese population" 25 : 688-693, 1995

31 "Angiotensinogen as a risk factor for essential hypertension in Japan" 93 : 1285-1287, 1994

32 "Angiotensinogen and blood pressure among blacks findings from a community survey in Jamaica" 14 : 315-321, 1996

33 "An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels" 86 : 1343-1346, 1990

34 "Alpha-ADD1 polymorphisms and renal sodium handling in essential hypertensive patients" 53 : 1471-1478, 1998

35 "Alpha-ADD1 G460W polymorphism, urinary sodium excretion, and blood pressure in community-based samples." 17 : 385-390, 2004

36 "Absence of linkage between the angiotensin converting enzyme locus and human essential hypertension" 1 : 72-75, 1992

37 "A polymorphism of the angiotensinogen gene associated with variation in blood pressure in a genetic isolate" 90 : 2207-2212, 1994