1 de la Cruz IP, "sup-9, sup-10, and unc-93 may encode components of a two-pore K+ channel that coordinates muscle contraction in Caenorhabditis elegans" 23 : 9133-9145, 2003
2 Girard C, "p11, an annexin II subunit, an auxiliary protein associated with the background K+ channel" 21 : 4439-4448, 2002
3 Cain SM, "mGlu4potentiation of K(2P)2.1 is dependant on C-terminal dephosphorylation" 37 : 32-39, 2008
4 Regan MR, "Variations in promoter activity reveal a differential expression and physiology of glutamate transporters by glia in the developing and mature CNS" 27 : 6607-6619, 2007
5 Kawamoto Y, "Upregulated expression of 14-3-3 proteins in astrocytes from human cerebrovascular ischemic lesions" 37 : 830-835, 2006
6 Kim JE, "Upregulated TWIKrelated acid-sensitive K+ channel-2 in neurons and perivascular astrocytes in the hippocampus of experimental temporal lobe epilepsy" 50 : 654-663, 2009
7 Rivera-Pagán AF, "Up-regulation of TREK-2 potassium channels in cultured astrocytes requires de novo protein synthesis: relevance to localization of TREK-2channels in astrocytes after transient cerebral ischemia" 10 : e0125195-, 2015
8 Kim DS, "Up-regulated astroglial TWIK-related acid-sensitive K+ channel-1 (TASK-1) in the hippocampus of seizure-sensitive gerbils: a target of anti-epileptic drugs" 1185 : 346-358, 2007
9 Talley EM, "Two-pore-Domain (KCNK) potassium channels: dynamic roles in neuronal function" 9 : 46-56, 2003
10 Cavelier P, "Tonic release of glutamate by a DIDS-sensitive mechanism in rat hippocampal slices" 564 : 397-410, 2005
11 Kang D, "Thermosensitivity of the twopore domain K+ channels TREK-2 and TRAAK" 564 : 103-116, 2005
12 Czirják G, "The two-pore domain K+ channel, TRESK, is activated by the cytoplasmic calcium signal through calcineurin" 279 : 18550-18558, 2004
13 Lesage F, "The structure, function and distribution of the mouse TWIK-1 K+ channel" 402 : 28-32, 1997
14 Honoré E, "The neuronal background K2P channels:focus on TREK1" 8 : 251-261, 2007
15 Minieri L, "The inhibitor of volume-regulated anion channels DCPIB activates TREK potassium channels in cultured astrocytes" 168 : 1240-1254, 2013
16 Feliciangeli S, "The family of K2P channels: salient structural and functional properties" 593 : 2587-2603, 2015
17 Wang DD, "The astrocyte odyssey" 86 : 342-367, 2008
18 Franks NP, "The TREK K2P channels and their role in general anaesthesia and neuroprotection" 25 : 601-608, 2004
19 Sirois JE, "The TASK-1 two-pore domain K+ channel is a molecular substrate for neuronal effects of inhalation anesthetics" 20 : 6347-6354, 2000
20 Satoh J, "The 14-3-3 protein epsilon isoform expressed in reactive astrocytes in demyelinating lesions of multiple sclerosis binds to vimentin and glial fibrillary acidic protein in cultured human astrocytes" 165 : 577-592, 2004
21 Blin S, "Tandem pore domain halothane-inhibited K+channel subunits THIK1 and THIK2 assemble and form active channels" 289 : 28202-28212, 2014
22 Chavez RA, "TWIK-2, a new weak inward rectifying member of the tandem pore domain potassium channel family" 274 : 7887-7892, 1999
23 Lesage F, "TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure" 15 : 1004-1011, 1996
24 Zhou M, "TWIK-1 and TREK-1 are potassium channels contributing significantly to astrocyte passive conductance in rat hippocampal slices" 29 : 8551-8564, 2009
25 Bittner S, "TREKking the blood-brain-barrier" 9 : 293-301, 2014
26 Bang H, "TREK-2, a new member of the mechanosensitive tandem-pore K+ channel family" 275 : 17412-17419, 2000
27 Heurteaux C, "TREK-1, a K+ channel involved in neuroprotection and general anesthesia" 23 : 2684-2695, 2004
28 Maingret F, "TREK-1 is a heat-activated background K(+) channel" 19 : 2483-2491, 2000
29 Woo DH, "TREK-1 and Best1 channels mediate fast and slow glutamate release in astrocytes upon GPCR activation" 151 : 25-40, 2012
30 Maingret F, "TRAAK is a mammalian neuronal mechano-gated K+channel" 274 : 1381-1387, 1999
31 Rajan S, "THIK-1and THIK-2, a novel subfamily of tandem pore domain K+channels" 276 : 7302-7311, 2001
32 Ashmole I, "TASK-5, a novel member of the tandem pore K+ channel family" 442 : 828-833, 2001
33 Kim D, "TASK-5, a new member of the tandem-pore K(+) channel family" 284 : 923-930, 2001
34 Rajan S, "TASK-3, a novel tandem pore domain acid-sensitive K+ channel. An extracellular histiding as pH sensor" 275 : 16650-16657, 2000
35 Kim Y, "TASK-3, a new member of the tandem pore K(+) channel family" 275 : 9340-9347, 2000
36 Talley EM, "TASK-1, a two-pore domain K+ channel, is modulated by multiple neurotransmitters in motoneurons" 25 : 399-410, 2000
37 Duprat F, "TASK, a human background K+ channel to sense external pH variations near physiological pH" 16 : 5464-5471, 1997
38 Kim Y, "Synergistic interaction and the role of C-terminus in the activation of TRAAK K+ channels by pressure, free fatty acids and alkali" 442 : 64-72, 2001
39 Kang D, "Single-channel properties and pH sensitivity of two-pore domain K+ channels of the TALK family" 315 : 836-844, 2004
40 Murbartián J, "Sequential phosphorylation mediates receptor- and kinase-induced inhibition of TREK-1 background potassium channels" 280 : 30175-30184, 2005
41 Plant LD, "SUMOylation silences heterodimeric TASK potassium channels containing K2P1 subunits in cerebellar granule neurons" 5 : ra84-, 2012
42 Kim JE, "Region-specific alterations in astroglial TWIK-related acid-sensitive K+-1channel immunoreactivity in the rat hippocampal complex following pilocarpine-induced status epilepticus" 510 : 463-474, 2008
43 Takano T, "Receptormediated glutamate release from volume sensitive channels in astrocytes" 102 : 16466-16471, 2005
44 Maljevic S, "Potassium channels: a review of broadening therapeutic possibilities for neurological diseases" 260 : 2201-2211, 2013
45 Choe S, "Potassium channel structures" 3 : 115-121, 2002
46 Kofuji P, "Potassium buffering in the central nervous system" 129 : 1045-1056, 2004
47 Czirják G, "Phosphorylationdependent binding of 14-3-3 proteins controls TRESK regulation" 283 : 15672-15680, 2008
48 Goldstein SA, "ORK1, a potassium-selective leak channel with two pore domains cloned from Drosophila melanogaster by expression in Saccharomyces cerevisiae" 93 : 13256-13261, 1996
49 Xiao Z, "Noradrenergic depression of neuronal excitability in the entorhinal cortex via activation of TREK-2 K+ channels" 284 : 10980-10991, 2009
50 Kunkel MT, "Mutants of a temperature-sensitive two-P domain potassium channel" 20 : 7517-7524, 2000
51 Sandoz G, "Mtap2 is a constituent of the protein network that regulates twik-related K+ channel expression and trafficking" 28 : 8545-8552, 2008
52 Berg AP, "Motoneurons express heteromeric TWIK-related acidsensitive K+ (TASK) channels containing TASK-1 (KCNK3)and TASK-3 (KCNK9) subunits" 24 : 6693-6702, 2004
53 Coetzee WA, "Molecular diversity of K+ channels" 868 : 233-285, 1999
54 Sabbadini M, "Molecular biology of background K channels: insights from K(2P) knockout mice" 385 : 1331-1344, 2009
55 Enyedi P, "Molecular background of leak K+currents: two-pore domain potassium channels" 90 : 559-605, 2010
56 Lesage F, "Molecular and functional properties of two-pore-domain potassium channels" 279 : F793-F801, 2000
57 Danthi S, "Modulation of native TREK-1 and Kv1.4 K+ channels by polyunsaturated fatty acids and lysophospholipids" 195 : 147-164, 2003
58 Maingret F, "Mechano- or acid stimulation, two interactive modes of activation of the TREK-1 potassium channel" 274 : 26691-26696, 1999
59 Chemin J, "Mechanisms underlying excitatory effects of group I metabotropic glutamate receptors via inhibition of 2P domain K+ channels" 22 : 5403-5411, 2003
60 Kang D, "Mechanism of inhibition of TREK-2 (K2P10.1) by the Gq-coupled M3 muscarinic receptor" 291 : C649-C656, 2006
61 Maingret F, "Lysophospholipids open the two-pore domain mechanogated K(+) channels TREK-1 and TRAAK" 275 : 10128-10133, 2000
62 Kindler CH, "Localization of the tandem pore domain K+ channel TASK-1 in the rat central nervous system" 80 : 99-108, 2000
63 Kim Y, "Localization of TREK-2 K+ channel domains that regulate channel kinetics and sensitivity to pressure, fatty acids and pHi" 442 : 952-960, 2001
64 Liu Y, "Linolenic acid provides multi-cellular protective effects after photothrombotic cerebral ischemia in rats" 39 : 1797-1808, 2014
65 Dong YY, "K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac" 347 : 1256-1259, 2015
66 Lipton P, "Ischemic cell death in brain neurons" 79 : 1431-1568, 1999
67 Kucheryavykh LY, "Ischemia increases trek-2 channel expression in astrocytes:Relevance to glutamate clearance" 3 : 40-47, 2009
68 Wu X, "Involvement of TREK-1 activity in astrocyte function and neuroprotection under simulated ischemia conditions" 49 : 499-506, 2013
69 Chen X, "Inhibition of a background potassium channel by Gq protein alphasubunits" 103 : 3422-3427, 2006
70 Patel AJ, "Inhalational anesthetics activate two-pore-domain background K+ channels" 2 : 422-426, 1999
71 Lesage F, "Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors" 275 : 28398-28405, 2000
72 Levitz J, "Heterodimerization within the TREK channel subfamily produces a diverse family of highly regulated potassium channels" 113 : 4194-4199, 2016
73 Jourdain P, "Glutamate exocytosis from astrocytes controls synaptic strength" 10 : 331-339, 2007
74 Girard C, "Genomic and functional characteristics of novel human pancreatic 2P domain K(+)channels" 282 : 249-256, 2001
75 Lee Y, "GFAP promoter elements required for region-specific and astrocyte-specific expression" 56 : 481-493, 2008
76 Deng PY, "GABA(B)receptor activation inhibits neuronal excitability and spatial learning in the entorhinal cortex by activating TREK-2 K+channels" 63 : 230-243, 2009
77 Bradley SJ, "G protein-coupled receptor signalling in astrocytes in health and disease: a focus on metabotropic glutamate receptors" 84 : 249-259, 2012
78 Kimelberg HK, "Functions of mature mammalian astrocytes: a current view" 16 : 79-106, 2010
79 Kimelberg HK, "Functions of astrocytes and their potential as therapeutic targets" 7 : 338-353, 2010
80 D'Ambrosio R, "Functional specialization and topographic segregation of hippocampal astrocytes" 18 : 4425-4438, 1998
81 Chu KC, "Functional identification of an outwardly rectifying pH- and anesthetic-sensitive leak K(+) conductance in hippocampal astrocytes" 32 : 725-735, 2010
82 Gnatenco C, "Functional expression of TREK-2 K+ channel in cultured rat brain astrocytes" 931 : 56-67, 2002
83 O'Kelly I, "Forward transport. 14-3-3 binding overcomes retention in endoplasmic reticulum by dibasic signals" 111 : 577-588, 2002
84 Lengyel M, "Formation of functional heterodimers by trek-1 and trek-2 two-pore domain potassium channel subunits" 291 : 13649-13661, 2016
85 Czirják G, "Formation of functional heterodimers between the TASK-1 and TASK-3 two-pore domain potassium channel subunits" 277 : 5426-5432, 2002
86 Sandoz G, "Extracellular acidification exerts opposite actions on TREK1 and TREK2 potassium channels via a single conserved histidine residue" 106 : 14628-14633, 2009
87 Cadaveira-Mosquera A, "Expression of K2P channels in sensory and motor neurons of the autonomic nervous system" 48 : 86-96, 2012
88 Kim E, "Enhancement of TREK1 channel surface expression by protein-protein interaction with beta-COP" 395 : 244-250, 2010
89 Megias L, "Endocytosis and transcytosis in growing astrocytes in primary culture. Possible implications in neural development" 44 : 209-221, 2000
90 Hamilton NB, "Do astrocytes really exocytose neurotransmitters?" 11 : 227-238, 2010
91 Hervieu GJ, "Distribution and expression of TREK-1, a two-pore-domain potassium channel, in the adult rat CNS" 103 : 899-919, 2001
92 Medhurst AD, "Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery" 86 : 101-114, 2001
93 Benesova J, "Distinct expression/function of potassium and chloride channels contributes to the diverse volume regulation in cortical astrocytes of GFAP/EGFP mice" 7 : e29725-, 2012
94 Lesage F, "Dimerization of TWIK-1 K+ channel subunits via a disulfide bridge" 15 : 6400-6407, 1996
95 Kaf itz KW, "Developmental profile and properties of sulforhodamine 101--labeled glial cells in acute brain slices of rat hippocampus" 169 : 84-92, 2008
96 Zhou M, "Development of GLAST(+) astrocytes and NG2(+) glia in rat hippocampus CA1: mature astrocytes are electrophysiologically passive" 95 : 134-143, 2006
97 Rajan S, "Daut J(2002)Interaction with 14-3-3 proteins promotes functional expression of the potassium channels TASK-1 and TASK-3" 545 : 13-26, 2002
98 Miller AN, "Crystal structure of the human two-pore domain potassium channel K2P1" 335 : 432-436, 2012
99 Brohawn SG, "Crystal structure of the human K2P TRAAK, a lipid- and mechanosensitive K+ ion channel" 335 : 436-441, 2012
100 Djukic B, "Conditional knock-out of Kir4.1 leads to glial membrane depolarization, inhibition of potassium and glutamate uptake, and enhanced short-term synaptic potentiation" 27 : 11354-11365, 2007
101 Talley EM, "Cns distribution of members of the two-pore-domain (KCNK)potassium channel family" 21 : 7491-7505, 2001
102 Fink M, "Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel" 15 : 6854-6862, 1996
103 Salinas M, "Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure" 274 : 11751-11760, 1999
104 Lesage F, "Cloning and expression of human TRAAK, a polyunsaturated fatty acidsactivated and mechano-sensitive K(+) channel" 471 : 137-140, 2000
105 Wang M, "Changes in lipid-sensitive two-pore domain potassium channel TREK-1 expression and its involvement in astrogliosis following cerebral ischemia in rats" 46 : 384-392, 2012
106 Kim JE, "Changes in TWIK-related acid sensitive K+-1 and -3 channel expressions from neurons to glia in the hippocampus of temporal lobe epilepsy patients and experimental animal model" 36 : 2155-2168, 2011
107 Nedergaard M, "Beyond the role of glutamate as a neurotransmitter" 3 : 748-755, 2002
108 Porter JT, "Astrocytic neurotransmitter receptors in situ and in vivo" 51 : 439-455, 1997
109 Oberheim NA, "Astrocytic complexity distinguishes the human brain" 29 : 547-553, 2006
110 Bezzi P, "Astrocytes contain a vesicular compartment that is competent for regulated exocytosis of glutamate" 7 : 613-620, 2004
111 Kang J, "Astrocyte-mediated potentiation of inhibitory synaptic transmission" 1 : 683-692, 1998
112 Anderson CM, "Astrocyte glutamate transport: review of properties, regulation, and physiological functions" 32 : 1-14, 2000
113 Haydon PG, "Astrocyte control of synaptic transmission and neurovascular coupling" 86 : 1009-1031, 2006
114 Seifert G, "Analysis of astroglial K+channel expression in the developing hippocampus reveals a predominant role of the Kir4.1 subunit" 29 : 7474-7488, 2009
115 Sandoz G, "AKAP150, a switch to convert mechano-, pH- and arachidonic acidsensitive TREK K(+) channels into open leak channels" 25 : 5864-5872, 2006
116 Cahoy JD, "A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function" 28 : 264-278, 2008
117 Sano Y, "A novel two-pore domain K+ channel, TRESK, is localized in the spinal cord" 278 : 27406-27412, 2003
118 Schewe M, "A non-canonical voltage-sensing mechanism controls gating in k2p k(+) channels" 164 : 937-949, 2016
119 Fink M, "A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids" 17 : 3297-3308, 1998
120 Patel AJ, "A mammalian two pore domain mechano-gated S-like K+ channel" 17 : 4283-4290, 1998
121 Millar JA, "A functional role for the two-pore domain potassium channel TASK-1 in cerebellar granule neurons" 97 : 3614-3618, 2000
122 Hwang EM, "A disulphide-linked heterodimer of TWIK-1 and TREK-1mediates passive conductance in astrocytes" 5 : 3227-, 2014