18F-FDG Positron-Emission Tomography/Computed Tomography Findings of Radiographic Lesions Suggesting Old Healed Tuberculosis

다국어 초록 (Multilingual Abstract)

The presence of radiographic lesions suggesting old healed tuberculosis (TB) is one of thestrongest risk factors for the subsequent development of active TB. We elucidated themetabolic activity of radiographic lesions suggesting old healed TB using18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDGPET/CT). This cross-sectional study included 63 participants with radiographic lesionssuggesting old healed TB and with available 18F-FDG PET/CT scans. The maximumstandardized uptake value (SUVmax) measured in the lesions, the clinical characteristics,results of the tuberculin skin test (TST) and interferon-γ release assay (IGRA) were analyzed.

The SUVmax in old healed TB was 1.5 or higher among nine (14.3%) participants. Age(adjusted odds ratio [aOR], 1.23; 95% CI, 1.03-1.46), history of previous TB (aOR, 60.43;95% CI, 1.71-2131.65), and extent of the lesions (aOR, 1.34; 95% CI, 1.02-1.75) wereassociated with higher SUVmax. The positive rates for the TST and IGRA were not differentbetween groups with and without increased FDG uptake. Increased FDG uptake on 18F-FDGPET/CT was observed in a subset of patients with radiographic lesions suggesting old healedTB. Given that the factors associated with increased FDG uptake are known risk factors forTB development, the possibility exists that participants with old healed TB lesions withhigher SUV on 18F-FDG PET/CT scans might be at higher risk for active TB.

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