Detection of Aberrant p16INK4A Methylation in Sera of Patients with Liver Cirrhosis and Hepatocellular Carcinoma

참고문헌 (Reference)

1 "Relationship of p16 methylation status and serum alpha-fetoprotein concentration in hepatocellular carcinoma patients" 46 : 1420-2, 2000

2 "Quantitative comparison of alpha-fetoprotein and albumin mRNA levels in hepatocellular carcinoma/adenoma, non-tumor liver and blood: implications in cancer detection and monitoring" 156 : 141-9, 2000

3 "Prognosis ofrecurrent hepatocellular carcinoma:a 10-year surgical experiencein Japan" 111 : 720-6, 1996

4 "Percutaneous ethanol injec-tion therapy for treatment of hepatocellular carcinoma" 154 : 947-51, 1990

5 "Mutation inthe p53 tumor suppressor gene:clues to cancer etiology and molec-ular pathogenesis" 54 : 4855-78, 1994

6 "Molecular pathogenesis of humanhepatocellular carcinoma" 31 : 339-46, 2002

7 "Methylation-specific PCR:a novel PCR assay for methylation status of CpG islands" 93 : 9821-6, 1996

8 "Methylation frame-work of cell cycle gene inhibitors in cirrhosis and associated hepa-tocellular carcinoma" 36 : 427-32, 2002

9 "Local ablation therapy for hepatocellular carcinoma" 19 : 323-8, 1999

10 "Infrequent mutations and no methylation of CDKN2A(p16/MTS1) and CDKN2B(p15/MTS2) in hepatocellular carcinomain Taiwan" 34 : 1789-95, 1998

11 "Infrequent alterations of the p16INK4Agene in liver cancers" 67 : 176-80, 1996

12 "Incidence andfactors associated with intrahepatic recurrence following resectionof hepatocellular carcinoma" 105 : 488-94, 1993

13 "High fre-quency of p16INKA4 gene alterations in hepatocellular carcinoma" 18 : 789-95, 1999

14 "Germ-line mutations of the p16INK4(MTS1)geneoccur in a subset of patients with hepatocellular carcinoma" 25 : 1376-81, 1997

15 "Germ-line mutations of the p16INK4(MTS1)gene occur ina subset of patients with hepatocellular carcinoma" 25 : 1376-81, 1997

16 "Genetic instability and aberrant DNA methylation in chronichepatitis and cirrhosis: A comprehensive study of loss of heterozy-gosity and microsatellite instability at 39 loci and DNA hypermethy-lation on 8 CpG islands in microdissected specimens from patientswith hepatocellular carcinoma" 32 : 970-9, 2000

17 "Genes involved in hepatocellular carci-noma:deregulation in cell cycling and apoptosis" 440 : 345-52, 2002

18 "Earlydetection of hepatocellular carcinoma increases the chance of treat-ment:Hong Kong experience" 31 : 330-5, 2000

19 "Detection of hypermethylationof the p16(INK4A) gene promoter in chronic hepatitis and cirrhosisassociated with hepatitis B or C virus" 48 (48): 372-7, 2001

20 "Detection of aberrant p16 methy-lation in the plasma and serum of liver cancers patients" 59 : 71-3, 1999

21 "CpG methylation, chromatin structure and gene silencing:a three-way connection" 17 : 4905-7, 1998

22 "Clinical management of hepatocellularcarcinoma. Conclusions of the Barcelona-2000 EASL conference.European Association for the Study of the Liver" 35 : 421-30, 2001

23 "Alterations of CDKN2 (MTS1/p16INK4A) gene in paraffin-embedded tumor tissues of human stom-ach, lung, cervix and liver cancers" 30 : 109-14, 1998

24 "A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4" 366 : 704-7, 1993

25 "5′CpG island methylation is associated withtranscriptional silencing of the tumour suppressor p16/CDKN2/MTS1in human cancers" 1 : 686-92, 1995