하악골 신장술 후 하치조신경의 조직학적 변화와 신경성장인자의 발현에 대한 연구 = HISTOLOGICAL CHANGES AND EXPRESSION OF NERVE GROWTH FACTOR IN THE INFERIOR ALVEOLAR NERVE AFTER DISTRACTION OSTEOGENESIS

다국어 초록 (Multilingual Abstract)

Distraction osteogenesis (DO) is frequently used technique in reconstruction of bony defects resulted from tumor resection, congenital deformity, and trauma in the maxillofacial region. Although the histologic and ultrastructural changes associated with distraction osteogenesis have been extensively described, the exact changing of the surrounding tissues, such as nerve tissues, were still unclear. This study observed the histological changes and the expression of nerve growth factor (NGF) in the inferior alveolar nerve (IAN) after distraction osteogenesis. Unilateral mandibular distraction (0.5 mm twice per day for 10 days) was performed in eight mongrel dogs. Two animals were sacrificed at 7, 14, 28 and 56 days after completion of distraction, respectively. The distracted IAN and contralateral control nerve were harvested and processed for histological and innunohistochemical examinations. The signs of acute nerve injuries, such as demyelination and partial discontinuation of nerver fiber, were observed in the distracted IAN on 7 and 14 days after distraction. The initial remyelination and regeneration of distracted IAN were showed at 14 days after completion of distraction. At 56 days later, the histologic features of distracted IAN was similar to those of the normal control IAN. The expression of NGF was significantly increased in most distracted nerve tissues on 7, 14 and 28 days after distraction. On 56 days after distraction, the expression of NGF returned to the normal level. This study suggested that the acute IAN injury caused by mandibular distraction were mostly recovered during consolidation period. The NGF was seemed to be induced from Schwann cell and damaged nerve tissues, and it may have important roles in the initial healing of damaged nerves.

참고문헌 (Reference)

1 "The tension-stress effect on the genesis and growth of tissues The influence of the rate and frequency of distraction" 1989

2 "The tension-stress effect on the genesis and growth of tissues The influence of stability of fixation and soft tissue preservation" 1989

3 "The role of nerve growth factor and brain-derived neurotrophic factor in inferior alveolar nerve regeneration in distraction osteogenesis" gia (gia): 2003

4 "The role of nerve growth factor and brain-derived neurotrophic factor in inferior alveolar nerve regeneration in distraction osteogenesis" gia (gia): 2003

5 "The nerve growth factor 35 years later" -237, 1987

6 "The biomechanical responses to tension in a peripheral nerve" 1980

7 "Stretch injury of peripheral nerve Acute effects of stretching on rabbit nerve" 1970

8 "Schwann cells, neurotrophic factors, and peripheral nerve regeneration" -18, 1998

9 "Response of Schwann cells in the inferior alveolar nerve to distraction osteogenesis" 2003

10 "Peripheral nerve damage during limb lengthening" (varina m) : 1990

11 "Mandibular lengthening in the craniofacial skeleton" 1973

12 "Lengthening the human mandible by gradual distraction" 1992

13 "Intraoral distraction osteogenesis for lengthening of the mandibular ascending ramus The Abstract Book of International Congress on Cranial and Facial Bone Distraction Process" 1997

14 "Interleukin-I regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve" -330, 1987

15 "Effects of mandibular distraction osteogenesis on the inferior alveolar nerve an experimental study in monkeys" 2002

16 "Effect of distraction osteogenesis on the peripheral nerve Experimental study in the rat" 1998

17 "Complications of bone lengthening" 1994

18 "Changes in the inferior alveolar nerve following mandibular lengthening in the dog using distraction osteogenesis" 1993

19 "Changes in the inferior alveolar nerve after mandibular lengthening with different rates of distraction" 2001

20 "Changes in canine peripheral nerves during experimental callus distraction" 2000

21 "Bone lengthening in the craniofacial skeleton" 1990