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      Verapamil이 心筋 小胞體의 Mg^++-Ca^++-ATPase 活性에 미치는 影響 = Effects of Verapamil on the Mg^++-Ca^++-ATPase Activity of Cardiac Sarcoplasmic Recticulum

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      https://www.riss.kr/link?id=A30007375

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      다국어 초록 (Multilingual Abstract)

      The present experiments were designed to investigate the effect of verapamil on the Mg^++-Ca^++-ATPase activity. The inhibitory effect of cardiac muscle contractility was measured by physiograph, and the effect of the drug on the Mg^++-Ca^++-ATPase activity was analyzed by enzyme kinetics such as Dixon plot and Lineweaver-Burk plot. The results obtained here were as follows :
      1. The contractility of the ventricular muscle was decreased to 74 % after 20min, infusion in the presence of verpamil(0.01mM). Though EDTA was also added to the infusion buffer, the inhibitory effect of verapamil was not changed.
      2. The concentration of 50% inhibition for verapamil coincided with the inhibition constant(Ki). The Ki value was 0.01 for verapamil.
      3. Verapamil did not change the Km value(5), but decrease V_max of the enzyme activity; suggesting that verapamil acts as a reversible and noncompetitive inhibitor.
      From the above results, verapamil inhibits the Mg^++-Ca^++-ATPase Activity as an noncompetitive inhibitor, and thus Ca^++ could not be released from cardiac sarcoplasmic reticulum.
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      The present experiments were designed to investigate the effect of verapamil on the Mg^++-Ca^++-ATPase activity. The inhibitory effect of cardiac muscle contractility was measured by physiograph, and the effect of the drug on the Mg^++-Ca^++-ATPase ac...

      The present experiments were designed to investigate the effect of verapamil on the Mg^++-Ca^++-ATPase activity. The inhibitory effect of cardiac muscle contractility was measured by physiograph, and the effect of the drug on the Mg^++-Ca^++-ATPase activity was analyzed by enzyme kinetics such as Dixon plot and Lineweaver-Burk plot. The results obtained here were as follows :
      1. The contractility of the ventricular muscle was decreased to 74 % after 20min, infusion in the presence of verpamil(0.01mM). Though EDTA was also added to the infusion buffer, the inhibitory effect of verapamil was not changed.
      2. The concentration of 50% inhibition for verapamil coincided with the inhibition constant(Ki). The Ki value was 0.01 for verapamil.
      3. Verapamil did not change the Km value(5), but decrease V_max of the enzyme activity; suggesting that verapamil acts as a reversible and noncompetitive inhibitor.
      From the above results, verapamil inhibits the Mg^++-Ca^++-ATPase Activity as an noncompetitive inhibitor, and thus Ca^++ could not be released from cardiac sarcoplasmic reticulum.

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