혈액인자가 관상동맥 석회화 수치에 미치는 영향 = Effects of Blood Factors on Coronary Artery Calcification Scores

국문 초록 (Abstract)

관상동맥 석회화는 심혈관질환 위험인자와 연관이 있으며, 동맥경화반의 양과 밀접한 관계가 있음을 선행 연구에서 보고되고 있다. 이에 본 연구에서는 2020년 12월부터 2021년 2월까지 대구시 소재 S 영상의학과 건강검진센터를 방문하여 관상동맥 Calcium scoring CT를 시행한 109명을 대상으로 혈액인자가 관상동맥 석회화 수치에 미치는 영향을 알아보고자 하였다. 연구결과 허리둘레 인자에서는 비정상 군이 정상 군에 비해 석회화 발생 위험도가 1.113배 증가하였고, 공복혈당 인자에서는 비정상 군이 정상 군에 비해 석회화 발생 위험도가 1.036배 증가하였으며, 중성지방 인자에서는 비정상 군이 정상 군에 비해 석회화 발생 위험도가 1.008배 증가하였으므로 허리둘레 인자와 공복혈당인자, 중성지방 인자가 관상동맥 석회화 수치에 영향을 주는 인자임을 알 수 있었다. 석회화 수치 발생 위험도는 허리둘레 인자와 공복혈당인자, 중성지방 인자와 유의한 관계가 있으므로 석회화 수치와 연관성이 있는 위험 변수들의 수치를 줄이기 위하여 평소 건강관리에 관심을 갖고 건강검진을 통하여 사전에 예방하기 위해 노력한다면 심혈관질환의 발생률을 낮추고, 심혈관질환과 관련된 의료비를 줄이는데 도움이 될 수 있을 것이라 기대한다.

다국어 초록 (Multilingual Abstract)

Coronary artery calcification is associated with cardiovascular risk factors and metabolic syndrome, and several studies have already reported that coronary artery calcification score are closely related to the amount of atherosclerotic plaques. This study was conducted on 109 patients who underwent coronary calcium CT who visited the comprehensive health examination center in Daegu city during the period from December 2020 to February 2021. we would like to investigate the relationship between coronary artery calcification score and blood factors. As a result of the study, the abnormal group increased the risk of calcification by 1.113 times compared to the normal group in the waist circumference factor. In the fasting glucose factor, the abnormal group increased the risk of calcification by 1.036 times compared to the normal group, and in the triglyceride factor, the abnormal group was normal. As the risk of calcification increased 1.008 times compared to the group, the waist circumference factor, fasting glucose factor, and triglyceride factor were found to be factors affecting coronary artery calcification score. The risk of developing calcification is primarily associated with waist circumference, anemia and triglycerides, and health care and health checks are expected to help reduce the incidence of cardiovascular disease and reduce medical costs.

목차 (Table of Contents)

• I. INTRODUCTION II. MATERIAL AND METHODS III. RESULT Ⅳ. DISCUSSION Ⅴ. CONCLUSION

참고문헌 (Reference)

1 오정환, "허혈성 심혈관 질환 선별을 위한 Calcium-scoring CT의 유용성" 대한방사선과학회 32 (32): 69-78, 2009

2 김혜련, "심장 CT 혈관 조영 영상 에서 대동맥 및 심문 자동 검출" (사)한국컴퓨터그래픽스학회 23 (23): 49-55, 2017

3 정인현, "선별검사 목적으로 시행된 관상동맥 CT의 석회수치에 따른 임상경과 관찰" 대한내과학회 78 (78): 466-476, 2010

4 정원주, "무증상 성인에서 대사증후군과 관상동맥석회화의 관련성" 대한임상건강증진학회 12 (12): 153-162, 2012

5 조영진, "무증상 성인에서 관상동맥 질환의 일차 예방 전략의 비교" 대한심장학회 38 (38): 483-490, 2008

6 김동희, "무증상 성인 한국인에서 관상동맥 석회 수치의 연령 및 성별 분포와 특성: 심혈관 질환의 위험요인 및 대사 증후군과의 관계" 대한심장학회 38 (38): 29-35, 2008

7 박승현, "다중절편 방사선단층촬영 결과에 기반한 한국 중년 남성에서의 관상동맥 석회화와 심혈관질환 위험인자와의 연관성" 한국농촌의학.지역보건학회 39 (39): 25-36, 2014

8 김영상, "관상동맥 석회 수치와 Framingham Risk Score와의 관계" 대한가정의학회 29 (29): 762-767, 2008

9 J. Y. Ko, "The usefulness of waist/height ratio as a predictor for the risk factors of coronary artery disease" 19 (19): 719-727, 1998

10 WHO, "The top 10 cause of death"

11 N. Ruderman, "The metabolically obese, normal-weight individual revisited" 47 (47): 699-713, 1998

12 H. M. Lakka, "The metabolic syndrome and total cardiovascular disese mortality in middle-aged men" 288 (288): 2709-2716, 2002

13 Franklin H. Epstein, "The Pathogenesis of Coronary Artery Disease and the Acute Coronary Syndromes" Massachusetts Medical Society 326 (326): 310-318, 1992

14 H. Y. Kim, "Relationships between Serum Uric Acid Level and Coronary Artery Calcium Score" 5 (5): 198-203, 2015

15 W. B. Kannel, "Regional obesity and risk of cardiovascular disease; the Framingham Study" 44 (44): 183-190, 1991

16 A. S. Agatston, "Quantification of coronary artery calcium using ultrafast computed tomography" 15 (15): 827-832, 1998

17 A. E. Cassidy, "Progression of subclinical coronary atherosclerosis: does obesity make a difference?" 14 (14): 32-33, 2005

18 F. Torremocha, "Prediction of major coronary events by coronary risk profile and silent myocardial ischaemia : prospective follow-up study of primary prevention in 72 diabetic patients" 27 (27): 49-57, 2001

19 A. Bener, "Obesity index that better predict metabolic syndrome: body mass index, waist circumference, waist hip ratio, or waist height ratio" 1-9, 2013

20 H. B. Hubert, "Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study" 67 (67): 968-977, 1983

21 D. B. Simons, "Noninvasive definition of anatomic coronary artery disease by ultrafast computed tomographic scanning: a quantitative pathologic comparison study" 20 (20): 1118-1126, 1995

22 M. K. Kim, "Metabolic syndrome" 55 (55): 1005-1013, 2012

23 Dariush Mozaffarian, "Heart Disease and Stroke Statistics—2016 Update" Ovid Technologies (Wolters Kluwer Health) 133 (133): 447-454, 2016

24 SD Hsieh, "Health risks among Japanese men with moderate body mass index" Springer Science and Business Media LLC 24 (24): 358-362, 2000

25 L. J. Shaw, "Electron Beam Computed Tomography for the Diagnosis and Prognosis of Coronary Artery Disease" 103 (103): 87-87, 2001

26 U. Hoffmann, "Effects of combined low-density lipoprotein apheresis and aggressive statin therapy on coronary calcified plaque as measured by computed tomography" 91 (91): 461-464, 2003

27 H. U. Rong, "Effect of metabolic syndrome on prognosis and clinical characteristics of revascularization in patients with coronary artery disease" 119 (119): 1871-1876, 2006

28 N. Wong, "Coronary artery calcium evaluation by electron beam computed tomography and its relation to new cardiovascular events" 86 (86): 495-498, 2000

29 E. K. Choi, "Coronary Computed Tomography Angiography as a Screening Tool for the Detection of Occult Coronary Artery Disease in Asymptomatic Individuals" 52 (52): 357-365, 2008

30 A. J. Taylor, "Coronary Calcium Independently Predicts Incident Premature Coronary Heart Disease Over Measured Cardiovascular Risk Factors: Mean Three-Year Outcomes in the Prospective Army Coronary Calcium (PACC) Project" 46 (46): 807-814, 2005

31 KOSIS, "Cause of death statistics"

32 O. H. Kwon, "Cardiovascular risk factors in men with normal and overweight according to waist-to-height ratio" 22 (22): 1757-1764, 2001

33 K. M. Sabah, "Body mass index and waist/height ratio for prediction of severity of coronary artery disease" 7 (7): 246-, 2014

34 C. K. Kramer, "Blood pressure and fasting plasma glucose rather than metabolic syndrome predict coronary artery calcium progression: the Rancho Bernardo Study" 32 (32): 141-146, 2009

35 Y. S. Park, "Association between Waist-to-Height Ratio and Metabolic Risk Factors in Korean Adults with Normal Body Mass Index and Waist Circumference" 228 (228): 1-8, 2012

36 J. Y. Shin, "Association between Coronary Artery Calcium Score and Fasting Glucose in Asymptomatic Subjects" 10 (10): 185-192, 2009

37 J. Y. Shin, "Association between Coronary Artery Calcium Score and Fasting Glucose in Asymptomatic Subjects" 10 (10): 185-192, 2009

38 J. Shemesh, "Annual progression of coronary artery calcium by spiral computed tomography in hypertensive patients without myocardial ischemia but with prominent atherosclerotic risk factors, in patients with previous angina pectoris or healed acute myocardial infarction, and in patients with coronary events during follow-up" 87 (87): 1395-1402, 2001

39 C. K. Kramer, "A prospective study of abdominal obesity and coronary artery calcium progression in older adults" 94 (94): 5039-5083, 2009