임상검체에서 분리된 세균의 항균제 감수성 : 1988-1992년 결과 = Antimicrobial Susceptibilities of Bacteria Isolated During 1988~1992

다국어 초록 (Multilingual Abstract)

Desite of availability of many antimicrobial agents, selection of drugs for treatment become very difficult, because of ever increasing resistant bacteria. As the resistance rates to drugs may vary greatly, depending on the species and the country of the isolation. It is important to know the current trend of resistance for the empiric therapy of patients. We analyzed the routine disk susceptibility test results at the Severance Hospital, during the years 1988-1992. During the period, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa remained to be the most frequently isolated species, while Acinetobacter baumannii, Enterobacter cloacae and Klebsiella pneumoniae were also prevalent. Increased isolation of Enterococcus was remarkable. These tendencies were considered to rellect increased resistance of these species. Methicillin-resistetant S.aureus, ampicillin-resistant Enterococcus and penicillin G-resistant Streptococcus pneumoniae were increased significantly. Increased resistance was also noted in E.coli, Citrobacter freundii, E.cloacae and A. baumannii, Although the resistance rates in our data may be relatively high, because the strains were mostly Isolated from inpatients, it is certain that resistant strains are more prevalent in Korea. In conclusion, this trend indicates that some drugs can be empirically selected with good predictable effect, while others with unpredictable effect. For durgs with unpredictable effect, susceptibility testing is required to guide selection of still effective old agents as much as possible to preserve the activity of newer agents the future.