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    Fabrication of Composite Drug Delivery System Using Nano Composite Deposition System and in vivo Characterization

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    https://www.riss.kr/link?id=A76266824

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    다국어 초록 (Multilingual Abstract) kakao i 다국어 번역

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    The Rapid Prototyping (RP) technology has advanced in many application areas. In this research, two different types, cylinder and scaffold. of implantable Drug Delivery System (DDS) were fabricated using Nano Composite Deposition System (NCDS), one of the RP systems. The anti-cancer drug (5-fluorouracil, 5-FU), biodegradable polymer (PLGA(85:15)), and bio ceramic (Hydroxyapatite, HA) were used to form drug-polymer composite material. Both types of DDS were evaluated in vivo environment for two weeks. For evaluation, the cumulative drug release and shape stability were measured. Test results showed that the scaffold DDS provide higher cumulative drug release and has better stability than cylinder DDS.
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    The Rapid Prototyping (RP) technology has advanced in many application areas. In this research, two different types, cylinder and scaffold. of implantable Drug Delivery System (DDS) were fabricated using Nano Composite Deposition System (NCDS), one of...

    The Rapid Prototyping (RP) technology has advanced in many application areas. In this research, two different types, cylinder and scaffold. of implantable Drug Delivery System (DDS) were fabricated using Nano Composite Deposition System (NCDS), one of the RP systems. The anti-cancer drug (5-fluorouracil, 5-FU), biodegradable polymer (PLGA(85:15)), and bio ceramic (Hydroxyapatite, HA) were used to form drug-polymer composite material. Both types of DDS were evaluated in vivo environment for two weeks. For evaluation, the cumulative drug release and shape stability were measured. Test results showed that the scaffold DDS provide higher cumulative drug release and has better stability than cylinder DDS.

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    목차 (Table of Contents)

    • 1. Introduction
    • 2. Materials and Methods
    • 3. Experimental Results and Discussions
    • 4. Conclusions
    • ACKNOWLEDGEMENT
    • 1. Introduction
    • 2. Materials and Methods
    • 3. Experimental Results and Discussions
    • 4. Conclusions
    • ACKNOWLEDGEMENT
    • REFERENCES
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