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5 Ariceta G, "The long-acting C5 inhibitor, ravulizumab, is effective and safe in pediatric patients with atypical hemolytic uremic syndrome naïve to complement inhibitor treatment" 100 : 225-237, 2021
6 Rondeau E, "The long-acting C5 inhibitor, ravulizumab, is effective and safe in adult patients with atypical hemolytic uremic syndrome naïve to complement inhibitor treatment" 97 : 1287-1296, 2020
7 Trouw LA, "The complement system as a potential therapeutic target in rheumatic disease" 13 : 538-547, 2017
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9 Legendre CM, "Terminal complement inhibitor eculizumab in atypical hemolytic-uremic syndrome" 368 : 2169-2181, 2013
10 Fakhouri F, "Terminal complement inhibitor eculizumab in adult patients with atypical hemolytic uremic syndrome : a single-arm, open-label trial" 68 : 84-93, 2016
1 Menne J, "Validation of treatment strategies for enterohaemorrhagic Escherichia coli O104 : H4 induced haemolytic uraemic syndrome : case-control study" 345 : e4565-, 2012
2 Zuber J, "Use of highly individualized complement blockade has revolutionized clinical outcomes after kidney transplantation and renal epidemiology of atypical hemolytic uremic syndrome" 30 : 2449-2463, 2019
3 Ring T, "Use of eculizumab in crescentic IgA nephropathy : proof of principle and conundrum?" 8 : 489-491, 2015
4 Welte T, "Treating C3 glomerulopathy with eculizumab" 19 : 7-, 2018
5 Ariceta G, "The long-acting C5 inhibitor, ravulizumab, is effective and safe in pediatric patients with atypical hemolytic uremic syndrome naïve to complement inhibitor treatment" 100 : 225-237, 2021
6 Rondeau E, "The long-acting C5 inhibitor, ravulizumab, is effective and safe in adult patients with atypical hemolytic uremic syndrome naïve to complement inhibitor treatment" 97 : 1287-1296, 2020
7 Trouw LA, "The complement system as a potential therapeutic target in rheumatic disease" 13 : 538-547, 2017
8 Hillmen P, "The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria" 355 : 1233-1243, 2006
9 Legendre CM, "Terminal complement inhibitor eculizumab in atypical hemolytic-uremic syndrome" 368 : 2169-2181, 2013
10 Fakhouri F, "Terminal complement inhibitor eculizumab in adult patients with atypical hemolytic uremic syndrome : a single-arm, open-label trial" 68 : 84-93, 2016
11 Zhang Y, "Targeting C3a/C5a receptors inhibits human mesangial cell proliferation and alleviates immunoglobulin A nephropathy in mice" 189 : 60-70, 2017
12 Jayne D, "Randomized trial of C5a receptor inhibitor avacopan in ANCA-associated vasculitis" 28 : 2756-2767, 2017
13 Walsh M, "Plasma exchange and glucocorticoids in severe ANCA-associated vasculitis" 382 : 622-631, 2020
14 Le Quintrec M, "Patterns of clinical response to eculizumab in patients with C3 glomerulopathy" 72 : 84-92, 2018
15 van Timmeren MM, "Pathogenesis of ANCA-associated vasculitis : recent insights from animal models" 24 : 8-14, 2012
16 Nakazawa D, "Pathogenesis and therapeutic interventions for ANCA-associated vasculitis" 15 : 91-101, 2019
17 Wingerchuk DM, "Long-term safety and efficacy of eculizumab in aquaporin-4 IgG-positive NMOSD" 89 : 1088-1098, 2021
18 Barbour T, "Long-term efficacy and safety of the long-acting complement C5 inhibitor ravulizumab for the treatment of atypical hemolytic uremic syndrome in adults" 6 : 1603-1613, 2021
19 Menne J, "Is ravulizumab the new treatment of choice for atypical hemolytic uremic syndrome(aHUS)?" 97 : 1106-1108, 2020
20 El Karoui K, "Impact of hypertensive emergency and rare complement variants on the presentation and outcome of atypical hemolytic uremic syndrome" 104 : 2501-2511, 2019
21 Bruel A, "Hemolytic uremic syndrome in pregnancy and postpartum" 12 : 1237-1247, 2017
22 Fakhouri F, "Haemolytic uraemic syndrome" 390 : 681-696, 2017
23 Timmermans S, "Functional and genetic landscape of complement dysregulation along the spectrum of thrombotic microangiopathy and its potential implications on clinical outcomes" 6 : 1099-1109, 2021
24 Licht C, "Efficacy and safety of eculizumab in atypical hemolytic uremic syndrome from 2-year extensions of phase 2 studies" 87 : 1061-1073, 2015
25 Walsh M, "Effects of duration of glucocorticoid therapy on relapse rate in antineutrophil cytoplasmic antibody-associated vasculitis : a meta-analysis" 62 : 1166-1173, 2010
26 Rosenblad T, "Eculizumab treatment for rescue of renal function in IgA nephropathy" 29 : 2225-2228, 2014
27 Rondeau E, "Eculizumab safety : five-year experience from the global atypical hemolytic uremic syndrome registry" 4 : 1568-1576, 2019
28 Socié G, "Eculizumab in paroxysmal nocturnal haemoglobinuria and atypical haemolytic uraemic syndrome : 10-year pharmacovigilance analysis" 185 : 297-310, 2019
29 Bomback AS, "Eculizumab for dense deposit disease and C3 glomerulonephritis" 7 : 748-756, 2012
30 Fakhouri F, "Eculizumab discontinuation in children and adults with atypical hemolytic-uremic syndrome : a prospective multicenter study" 137 : 2438-2449, 2021
31 Brodsky RA, "Eculizumab and aHUS : to stop or not" 137 : 2419-2420, 2021
32 Noris M, "Dynamics of complement activation in aHUS and how to monitor eculizumab therapy" 124 : 1715-1726, 2014
33 Timmermans S, "Diagnostic and risk factors for complement defects in hypertensive emergency and thrombotic microangiopathy" 75 : 422-430, 2020
34 Koopman J, "Deposition of the membrane attack complex in healthy and diseased human kidneys" 11 : 599974-, 2021
35 Walport MJ, "Complement. First of two parts" 344 : 1058-1066, 2001
36 Le Quintrec M, "Complement mutation-associated de novo thrombotic microangiopathy following kidney transplantation" 8 : 1694-1701, 2008
37 Zipfel PF, "Complement inhibitors in clinical trials for glomerular diseases" 10 : 2166-, 2019
38 Caravaca-Fontan F, "Complement inhibitors are useful in secondary hemolytic uremic syndromes" 96 : 826-829, 2019
39 Duineveld C, "Complement inhibitors are not useful in secondary hemolytic uremic syndromes" 96 : 829-833, 2019
40 Palma L, "Complement in secondary thrombotic microangiopathy" 6 : 11-23, 2021
41 Frémeaux-Bacchi V, "Complement gene variants and Shiga toxin-producing Escherichia coli-associated hemolytic uremic syndrome : retrospective genetic and clinical study" 14 : 364-377, 2019
42 Palomo M, "Complement activation and thrombotic microangiopathies" 14 : 1719-1732, 2019
43 Xiao H, "C5a receptor(CD88)blockade protects against MPO-ANCA GN" 25 : 225-231, 2014
44 Ruggenenti P, "C5 convertase blockade in membranoproliferative glomerulonephritis : a single-arm clinical trial" 74 : 224-238, 2019
45 Smith R, "C3 glomerulopathy : understanding a rare complement-driven renal disease" 15 : 129-143, 2019
46 Kielstein JT, "Best supportive care and therapeutic plasma exchange with or without eculizumab in Shiga-toxin-producing E. coli O104:H4 induced haemolytic-uraemic syndrome: an analysis of the German STEC-HUS registry" 27 : 3807-3815, 2012
47 Jayne D, "Avacopan for the treatment of ANCA-associated vasculitis" 384 : 599-609, 2021
48 Le Clech A, "Atypical and secondary hemolytic uremic syndromes have a distinct presentation and no common genetic risk factors" 95 : 1443-1452, 2019
49 Galbusera M, "An ex vivo test of complement activation on endothelium for individualized eculizumab therapy in hemolytic uremic syndrome" 74 : 56-72, 2019
50 Merkel PA, "Adjunctive treatment with avacopan, an oral c5a receptor inhibitor, in patients with antineutrophil cytoplasmic antibody-associated vasculitis" 2 : 662-671, 2020