신경릉 기원세포의 피부종양에서 S-100단백의 면역조직화학적 연구 = Immunohistochemical study of s-100 protein in skin tumors derived from cells of neural crest origin

다국어 초록 (Multilingual Abstract)

By permitting of cell-specific antigens, immunohistochemistry adds a new dimension to the identification of cells not recognizable by morphologic features alone, It also has the advantage of being applicable to routine paraffin-embedded histologic sections.
We examined the presence of S100 Protein in 33 cases of skin tumors derived from cells of neural crest origin, by immunohistochemical technique (ABC method).
The results obtained are as follows :
1. Of 33 cases of skin tumors derived from cells of neural crest origin, 30 were positively stained for S100 Protein.
2. S100 Protein was found in most of tumora derived from Schwann cell and melanocyte but blue nevi and Ota nevi contained little or no S100 protein.
3. In pigmerited nevi, compound nevi and intradermal nevi were more strongly stain for S100 protein than junctional nevi.
4. The intensity of S100 protein immunostaining was far less in neurofibroma than in neurilemmoma and was strongest in malignant melanoma.
5. Our results suggest that S100 protein is widely distributed among pigmented nevi and melanotic tumors and is also a very useful diagnostic indicator for skin tumors derived from cells of neural crest origin.