Strategies for ensuring that regenerative cardiomyocytes function properly and in cooperation with the host myocardium

다국어 초록 (Multilingual Abstract)

In developed countries, in which people have nutrient-rich diets, convenient environments, and access to numerous medications, the disease paradigm has changed. Nowadays, heart failure is one of the major causes of death. In spite of this, the therapeutic efficacies of medications are generally unsatisfactory.
Although whole heart transplantation is ideal for younger patients with heart failure, many patients are deemed to be unsuitable for this type of surgery due to complications and/or age. The need for therapeutic alternatives to heart transplantation is great. Regenerative therapy is a strong option. For this purpose, several cell sources have been investigated, including intrinsic adult stem or progenitor cells and extrinsic pluripotent stem cells. Most intrinsic stem cells seem to contribute to a regenerative environment via paracrine factors and/or angiogenesis, whereas extrinsic pluripotent stem cells are unlimited sources of cardiomyocytes.
In this review, we summarize the various strategies for using regenerative cardiomyocytes including our recent progressions: non-genetic approaches for the purification of cardiomyocytes and efficient transplantation. We expect that use of intrinsic and extrinsic stem cells in combination will enhance therapeutic effectiveness.

참고문헌 (Reference)

1 Pandur P, "Wnt-11 activation of a non-canonical Wnt signalling pathway is required for cardiogenesis" 418 : 636-641, 2002

2 Dow J, "Washout of transplanted cells from the heart: a potential new hurdle for cell transplantation therapy" 67 : 301-307, 2005

3 Hosseinkhani M, "Trichostatin A induces myocardial differentiation of monkey ES cells" 356 : 386-391, 2007

4 Yuasa S, "Transient inhibition of BMP signaling by Noggin induces cardiomyocyte differentiation of mouse embryonic stem cells" 23 : 607-611, 2005

5 Anderson D, "Transgenic enrichment of cardiomyocytes from human embryonic stem cells" 15 : 2027-2036, 2007

6 Prokhorova TA, "Teratoma Formation by Human Embryonic Stem Cells is site-dependent and enhanced by the presence of Matrigel" 2008

7 Kaneko Y, "Synthesis and swelling-deswelling kinetics of poly(N-isopropylacrylamide) hydrogels grafted with LCST modulated polymers" 10 : 1079-1091, 1999

8 Reinecke H, "Survival, integration, and differentiation of cardiomyocyte grafts: a study in normal and injured rat hearts" 100 : 193-202, 1999

9 Muller-Ehmsen J, "Survival and development of neonatal rat cardiomyocytes transplanted into adult myocardium" 34 : 107-116, 2002

10 Passier R, "Stem-cell-based therapy and lessons from the heart" 453 : 322-329, 2008

11 Muller M, "Selection of ventricular-like cardiomyocytes from ES cells in vitro" 14 : 2540-2548, 2000

12 Sauer H, "Role of reactive oxygen species and phosphatidylinositol 3-kinase in cardiomyocyte differentiation of embryonic stem cells" 476 : 218-223, 2000

13 Wobus AM, "Retinoic acid accelerates embryonic stem cell-derived cardiac differentiation and enhances development of ventricular cardiomyocytes" 29 : 1525-1539, 1997

14 Hattan N, "Purified cardiomyocytes from bone marrow mesenchymal stem cells produce stable intracardiac grafts in mice" 65 : 334-344, 2005

15 Furuta A, "Pulsatile cardiac tissue grafts using a novel three-dimensional cell sheet manipulation technique functionally integrates with the host heart, in vivo" 98 : 705-712, 2006

16 Laugwitz KL, "Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages" 433 : 647-653, 2005

17 Stary M, "Parietal endoderm secreted SPARC promotes early cardiomyogenesis in vitro" 310 : 331-343, 2005

18 Paquin J, "Oxytocin induces differentiation of P19 embryonic stem cells to cardiomyocytes" 9550-9555, 2002

19 Suzuki R, "Omentopexy enhances graft function in myocardial cell sheet transplantation" 387 : 353-359, 2009

20 Hattori F, "Nongenetic method for purifying stem cell-derived cardiomyocytes" 7 : 61-66,

21 Shimizu T, "Long-term survival and growth of pulsatile myocardial tissue grafts engineered by the layering of cardiomyocyte sheets" 12 : 499-507, 2006

22 Takahashi K, "Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors" 126 : 663-676, 2006

23 Takahashi K, "Induction of pluripotent stem cells from adult human fibroblasts by defined factors" 131 : 861-872, 2007

24 Zhu DY, "Inducible effects of icariin, icaritin, and desmethylicaritin on directional differentiation of embryonic stem cells into cardiomyocytes in vitro" 26 : 477-485, 2005

25 Passier R, "Increased cardiomyocyte differentiation from human embryonic stem cells in serum-free cultures" 23 : 772-780, 2005

26 van Laake LW, "Human embryonic stem cell-derived cardiomyocytes survive and mature in the mouse heart and transiently improve function after myocardial infarction" 1 : 9-24, 2007

27 Roggia C, "Hepatocyte growth factor (HGF) enhances cardiac commitment of differentiating embryonic stem cells by activating PI3 kinase" 313 : 921-930, 2007

28 Klug MG, "Genetically selected cardiomyocytes from differentiating embronic stem cells form stable intracardiac grafts" 98 : 216-224, 1996

29 Soonpaa MH, "Formation of nascent intercalated disks between grafted fetal cardiomyocytes and host myocardium" 264 : 98-101, 1994

30 Laflamme MA, "Formation of human myocardium in the rat heart from human embryonic stem cells" 167 : 663-671, 2005

31 Kiefer JC, "Epigenetics in development" 236 : 1144-1156, 2007

32 E LL, "Enrichment of cardiomyocytes derived from mouse embryonic stem cells" 25 : 664-674, 2006

33 Kolossov E, "Engraftment of engineered ES cell-derived cardiomyocytes but not BM cells restores contractile function to the infarcted myocardium" 203 : 2315-2327, 2006

34 Zimmermann WH, "Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts" 12 : 452-458, 2006

35 Gassanov N, "Endothelin induces differentiation of ANP-EGFP expressing embryonic stem cells towards a pacemaker phenotype" 18 : 1710-1712, 2004

36 Asahara T, "Endothelial progenitor cells for vascular medicine" 127 : 841-845, 2007

37 Kehat I, "Electromechanical integration of cardiomyocytes derived from human embryonic stem cells" 22 : 1282-1289, 2004

38 Moore JC, "Distinct cardiogenic preferences of two human embryonic stem cell (hESC) lines are imprinted in their proteomes in the pluripotent state" 372 : 553-558, 2008

39 Schroeder M, "Differentiation and lineage selection of mouse embryonic stem cells in a stirred bench scale bioreactor with automated process control" 92 : 920-933, 2005

40 Bauwens C, "Development of a perfusion fed bioreactor for embryonic stem cell-derived cardiomyocyte generation: oxygen-mediated enhancement of cardiomyocyte output" 90 : 452-461, 2005

41 Harrison NJ, "Culture adaptation of embryonic stem cells echoes germ cell malignancy" 30 : 275-281, 2007

42 Guo XM, "Creation of engineered cardiac tissue in vitro from mouse embryonic stem cells" 113 : 2229-2237, 2006

43 Zhao YS, "Construction of a unidirectionally beating 3-dimensional cardiac muscle construct" 24 : 1091-1097, 2005

44 Fink C, "Chronic stretch of engineered heart tissue induces hypertrophy and functional improvement" 14 : 669-679, 2000

45 Singh AM, "Chibby, an antagonist of the Wnt/beta-catenin pathway, facilitates cardiomyocyte differentiation of murine embryonic stem cells" 115 : 617-626, 2007

46 Hidaka K, "Chamber-specific differentiation of Nkx2.5-positive cardiac precursor cells from murine embryonic stem cells" 17 : 740-742, 2003

47 Masuda S, "Cell sheet engineering for heart tissue repair" 60 : 277-285, 2008

48 Fijnvandraat AC, "Cardiomyocytes purified from differentiated embryonic stem cells exhibit characteristics of early chamber myocardium" 35 : 1461-1472, 2003

49 Makino S, "Cardiomyocytes can be generated from marrow stromal cells in vitro" 103 : 697-705, 1999

50 Watanabe E, "Cardiomyocyte transplantation in a porcine myocardial infarction model" 7 : 239-246, 1998

51 Tomita Y, "Cardiac neural crest cells contribute to the dormant multipotent stem cell in the mammalian heart" 170 : 1135-1146, 2005

52 Oh H, "Cardiac muscle plasticity in adult and embryo by heart-derived progenitor cells" 1015 : 182-189, 2004

53 Scorsin M, "Can grafted cardiomyocytes colonize peri-infarct myocardial areas?" 94 : II337-II340, 1996

54 Hosseinkhani M, "Bone morphogenetic protein-4 enhances cardiomyocyte differentiation of cynomolgus monkey ESCs in knockout serum replacement medium" 25 : 571-580, 2007

55 Leor J, "Bioengineered cardiac grafts: A new approach to repair the infarcted myocardium?" 102 : III56-III61, 2000

56 Beltrami AP, "Adult cardiac stem cells are multipotent and support myocardial regeneration" 114 : 763-776, 2003

57 Itabashi Y, "A new method for manufacturing cardiac cell sheets using fibrin-coated dishes and its electrophysiological studies by optical mapping" 29 : 95-103, 2005

58 Rourou S, "A microcarrier cell culture process for propagating rabies virus in Vero cells grown in a stirred bioreactor under fully animal component free conditions" 25 : 3879-3889, 2007

59 최승철, "5-azacytidine induces cardiac differentiation of P19 embryonic stem cells" 생화학분자생물학회 36 (36): 515-523, 2004

60 Kanno S, "2nd Nitric oxide facilitates cardiomyogenesis in mouse embryonic stem cells" 12277-12281, 2004