감태 에탄올 추출물의 식중독 노로바이러스에 대한 저해 효과 = Inhibitory Effects of Ecklonia cava Ethanol Extract against Noroviruses Causing Foodborne Diseases

다국어 초록 (Multilingual Abstract)

Purpose: Human norovirus infections are a significant cause of viral foodborne outbreaks worldwide. The purpose of this study was to determine the inhibitory effects of Ecklonia cava ethanol extract against human norovirus surrogates, feline calicivirus-F9 (FCV) and murine norovirus-1 (MNV). Methods: Ecklonia cava was extracted with 70% ethanol and then lyophilized. The inhibitory effects of the extract against the foodborne viral surrogates were analyzed using time-of-addition plaque assays. The glutathione level and antioxidant effects were determined. Results: In the pretreatment and cotreatment of the virus, the Ecklonia cava ethanol extract exhibited inhibitory effects against FCV and MNV in a dose-dependent manner. The FCV- or MNV-infected cells treated with 100 μg/mL showed significantly increased glutathione levels, compared to those in the virus-infected cells. Ecklonia cava also exhibited DPPH radical scavenging activity and ferric ion reducing activity. Conclusion: Ecklonia cava can be developed as a novel algae-derived anti-norovirus food material against foodborne viral diseases.

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