배경: TREM-1은 중성구, 단핵구, 대식세포 표면에 존재하는 세포표면수용체로, 세균에 의해 그 발현이 증가하여 여러 염증전달물질을 증폭시키는 역할을 한다. 저자들은 삼출성흉수를 가진 환...
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https://www.riss.kr/link?id=A75456180
2007
-
500
SCOPUS,KCI등재,ESCI
학술저널
499-505(7쪽)
0
0
상세조회0
다운로드국문 초록 (Abstract)
배경: TREM-1은 중성구, 단핵구, 대식세포 표면에 존재하는 세포표면수용체로, 세균에 의해 그 발현이 증가하여 여러 염증전달물질을 증폭시키는 역할을 한다. 저자들은 삼출성흉수를 가진 환...
배경: TREM-1은 중성구, 단핵구, 대식세포 표면에 존재하는 세포표면수용체로, 세균에 의해 그 발현이 증가하여 여러 염증전달물질을 증폭시키는 역할을 한다. 저자들은 삼출성흉수를 가진 환자의 혈청과 흉수에서 soluble (s) TREM-1을 측정하여 흉수의 원인 진단에 대한 유용성을 알아보고자 하였다. 방법: 2003년 3월부터 2006년 12월까지 삼출성흉수로 입원한 환자 45명을 대상으로 하여, 혈청과 흉수에서 human sTREM-1 항체를 사용하여 면역점적법(immunoblot assay)으로 sTREM-1을 측정하였다. 원인질환에 따라 결핵성, 부폐렴성, 악성흉수로 나누어 비교하였다. 결과: 혈청 sTREM-1은 원인질환 별로 유의한 차이를 보이지 않았으나, 흉수 sTREM-1은 원인질환 별로 유의한 차이를 보였으며(p=0.011), 특히 부폐렴성흉수의 sTREM-1이 결핵성흉수와(p<0.05) 악성흉수보다 유의하게 높았다(p<0.05). 부폐렴성흉수를 진단하는 데 흉수 sTREM-1의 유용성을 평가하고자 ROC 곡선을 그린 결과 곡선밑면적은 0.818이고(p=0.001), 흉수 sTREM-1의 cutoff 값을 103.5 pg/mL로 하였을 때 민감도가 73%, 특이도가 81%이었다. 결론: 흉수의 sTREM-1은 삼출성흉수 중 부폐렴성흉수를 진단하는 유용한 지표로 판단된다.
다국어 초록 (Multilingual Abstract)
Background: Triggering receptor expressed on myeloid cells 1 protein (TREM-1) is a cell surface molecule expressed on neutrophils and monocytes, and it plays an important role in myeloid cell-activated inflammatory response. The aim of this study was ...
Background: Triggering receptor expressed on myeloid cells 1 protein (TREM-1) is a cell surface molecule expressed on neutrophils and monocytes, and it plays an important role in myeloid cell-activated inflammatory response. The aim of this study was to investigate the diagnostic efficiency of soluble (s) TREM-1 in the patients who had pleural effusion from various causes. Methods: Forty-five patients with exudative pleural effusion were included in this study. The level of sTREM-1 was measured in both the serum and pleural fluids by immunoblot assay with using human-sTREM-1 antibody. Results: The pleural fluid sTREM-1 was significantly different in the three groups of exudative pleural effusion (p=0.011). Particularly, the patients with parapneumonic effusion were found to have significantly higher pleural fluid levels of sTREM-1 than patients with tuberculous (p<0.05) and malignant effusion, respectively (p<0.05). However, the serum sTREM-1 did not show a significant difference in the three groups. In order to evaluate the diagnostic utility of pleural fluid sTREM-1, the receiver operating characteristic (ROC) curve was constructed and the area under the curve (AUC) was 0.818 (p=0.001). Using a cutoff value of 103.5 pg/mL for the pleural fluid sTREM-1, the sensitivity and specificity were 73% and 81%, respectively, for differentiating parapneumonic effusion from tuberculous or malignant effusions. Conclusion: Pleural fluid sTREM-1 can be an additional marker for making the differential diagnosis of pleural effusion. (Tuberc Respir Dis 2007; 62: 499-505)
참고문헌 (Reference)
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1 "Tuberculous pleurisy:a study of 254 patients" 158 : 2017-2021, 1998
2 "Tuberculous pleurisy" 63 : 88-92, 1973
3 "Triggering receptor expressed on myeloid cells:role in the diagnosis of lung infections" 24 : 247-250, 2004
4 "Triggering receptor expressed on myeloid cells-1 in pleural effusions:A marker of inflammatory disease" 101 : 903-909, 2007
5 "Time-course of sTREM (soluble triggering receptor expressed on myeloid cells)-1, procalcitonin, and C-reactive protein plasma concentrations during sepsis" 33 : 792-796, 2005
6 "TREM-1 amplifies inflammation and is a crucial mediator of septic shock" 410 : 1103-1107, 2001
7 "Surface triggering receptor expressed on myeloid cells 1 expression patterns in septic shock" 31 : 594-597, 2005
8 "Studies on delayed hypersensitivity pleural exudates in guinea pigs The interrelationship of monocytic and lymphocytic cells with respect to migration activity" 513-9, immunology1976
9 "Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia" 350 : 451-458, 2004
10 "Pleural effusions:the diagnostic sepreration of transudates and exudates" 77 : 507-13, 1972
11 "Pleural diseases" Philadelphia: Lippincott Williams & Wilkins 2001
12 "Plasma level of a triggering receptor expressed on myeloid cells-1:its diagnostic accuracy in patients with suspected sepsis" 141 : 9-15, 2004
13 "Monocytes as a site of production of soluble triggering receptor expressed on myeloid cells-1(sTREM-1)in the septic host" 38 : 909-915, 2006
14 "Glucose and amylase in pleural effusions" 225 : 257-60, 1973
15 "Diagnostic utility of serum and pleural fluid carcinoembryonic antigen, neuron- specific enolase, and cytokeratin 19 fragments in patients with effusions from primary lung cancer" 128 : 2298-2303, 2005
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17 "Diagnostic efficacy of pleural biopsy as compared with that of pleural fluid examination" 4 : 320-4, 1991
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19 "Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes" 164 : 4991-4995, 2000
20 "Cells in pleural fluid Their value in differential diagnosis" 854-60,
21 "Adenosine deaminase in pleural fluids Test for diagnosis of tuberculous pleural effusion" 51-3, chest1983
22 "A soluble form of the triggering receptor expressed on myeloid cells-1 modulates the inflammatory response in murine sepsis" 200 : 1419-1426, 2004
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화상 중환자실과 비화상 중환자실 폐 침윤 환자에서 기관지폐포 세척술 (BAL)을 통해 획득한 호흡기 검체에서 분리된 균주에 대한 항균제 내성 실태
학술지 이력
연월일 | 이력구분 | 이력상세 | 등재구분 |
---|---|---|---|
2023 | 평가예정 | 해외DB학술지평가 신청대상 (해외등재 학술지 평가) | |
2020-01-01 | 평가 | 등재학술지 유지 (해외등재 학술지 평가) | |
2011-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2009-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2007-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2004-07-30 | 학술지명변경 | 한글명 : 결핵 및 호흡기질환 -> Tuberculosis and Respiratory Diseases | |
2004-01-01 | 평가 | 등재학술지 선정 (등재후보2차) | |
2003-01-01 | 평가 | 등재후보 1차 PASS (등재후보1차) | |
2002-01-01 | 평가 | 등재후보학술지 유지 (등재후보1차) | |
2000-01-01 | 평가 | 등재후보학술지 선정 (신규평가) |
학술지 인용정보
기준연도 | WOS-KCI 통합IF(2년) | KCIF(2년) | KCIF(3년) |
---|---|---|---|
2016 | 0.21 | 0.21 | 0.2 |
KCIF(4년) | KCIF(5년) | 중심성지수(3년) | 즉시성지수 |
0.19 | 0.15 | 0.475 | 0.2 |