1 Bosi E, "Vildagliptin plus metformin combination therapy provides superior glycaemic control to individual monotherapy in treatment-naive patients with type 2 diabetes mellitus" 11 : 506-515, 2009
2 Dejager S, "Vildagliptin in drugnaïve patients with type 2 diabetes: a 24-week, double-blind, randomized, placebo-controlled, multiple-dose study" 39 : 218-223, 2007
3 Filippatos TD, "The pharmacokinetic considerations and adverse effects of DPP-4 inhibitors [corrected]" 10 : 787-812, 2014
4 DeFronzo RA, "The efficacy and safety of saxagliptin when added to metformin therapy in patients with inadequately controlled type 2 diabetes with metformin alone" 32 : 1649-1655, 2009
5 Moon JY, "The dose-dependent organ-specific effects of a dipeptidyl peptidase-4 inhibitor on cardiovascular complications in a model of type 2 diabetes" 11 : e0150745-, 2016
6 Hwang HJ, "The dipeptidyl peptidase-IV inhibitor inhibits the expression of vascular adhesion molecules and inflammatory cytokines in HUVECs via Akt- and AMPK-dependent mechanisms." 405 : 25-34, 2015
7 Morishita R, "Teneligliptin: expectations for its pleiotropic action" 16 : 417-426, 2015
8 American Diabetes Association., "Standards of medical care in diabetes: 2014" 37 (37): S14-S80, 2014
9 Jadzinsky M, "Saxagliptin given in combination with metformin as initial therapy improves glycaemic control in patients with type 2 diabetes compared with either monotherapy:a randomized controlled trial" 11 : 611-622, 2009
10 Taskinen MR, "Safety and efficacy of linagliptin as addon therapy to metformin in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled study" 13 : 65-74, 2011
11 정권수, "Renoprotective Effect of Gemigliptin, a Dipeptidyl Peptidase-4 Inhibitor, in Streptozotocin-Induced Type 1 Diabetic Mice" 대한당뇨병학회 40 (40): 211-221, 2016
12 Rizzo MR, "Reduction of oxidative stress and inflammation by blunting daily acute glucose fluctuations in patients with type 2 diabetes: role of dipeptidyl peptidase-IV inhibition" 35 : 2076-2082, 2012
13 Omar B, "Pleiotropic mechanisms for the glucoselowering action of DPP-4 inhibitors" 63 : 2196-2202, 2014
14 Aroor AR, "Pleiotropic effects of the dipeptidylpeptidase-4 inhibitors on the cardiovascular system" 307 : H477-H492, 2014
15 Baetta R, "Pharmacology of dipeptidyl peptidase-4inhibitors: similarities and differences" 71 : 1441-1467, 2011
16 Kim SH, "Pharmacological profiles of gemigliptin (LC15-0444), a novel dipeptidyl peptidase-4 inhibitor, in vitro and in vivo" 788 : 54-64, 2016
17 Lim KS, "Pharmacokinetics, pharmacodynamics, and tolerability of the dipeptidyl peptidase IV inhibitor LC15-0444 in healthy Korean men: a dose-block-randomized, double-blind, placebo-controlled, ascending single-dose, phase I study" 30 : 1817-1830, 2008
18 Lim KS, "Pharmacokinetics and pharmacodynamics of LC15-0444, a novel dipeptidyl peptidase IV inhibitor, after multiple dosing in healthy volunteers" 68 : 883-890, 2009
19 Shin D, "Pharmacokinetic and pharmacodynamic interaction between gemigliptin and metformin in healthy subjects" 34 : 383-393, 2014
20 Yoon S, "No. 804: Efficacy and safety of gemigliptin in type 2 diabetes patients with moderate to severe renal impairment" 2015
21 Lee BW, "No. 803: Effects of gemigliptin versus sitagliptin or glimepiride on glycaemic variability as initial combination therapy with metformin in drugnaïve patients with type 2 diabetes" 2015
22 Yoon S, "No. 1199:Efficacy and safety of gemigliptin in type 2 diabetes patients with moderate to severe renal impairment" 2016
23 Kim SH, "No. 1169: Efficacy and safety of gemigliptin as add-on therapy in patients with type 2 diabetes inadequately controlled on metformin and glimepiride" 2016
24 Rhee EJ, "No. 1128: Efficacy and safety of gemigliptin compared with sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone" 2012
25 Rhee EJ, "No. 111: Gemigliptin added to ongoing metformin therapy provides sustained glycemic control over 52 weeks and was well tolerated in patients with type 2 diabetes" 2013
26 Lim S, "No. 109: Efficacy and safety of gemigliptin/metformin initial combination therapy versus either as monotherapy in drug-naïve patients with type 2 diabetes" 2015
27 Cho YM, "New clinical experience of gemigliptin, the new DPPIV inhibitor" 2012
28 Zemiglo, "Ministry of Food and Drug Safety (MFDS) Package insert"
29 Inzucchi SE, "Management of hyperglycemia in type 2 diabetes: a patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)" 35 : 1364-1379, 2012
30 Barnett AH, "Linagliptin monotherapy in type 2 diabetes patients for whom metformin is inappropriate: an 18-week randomized, double-blind, placebo-controlled phase III trial with a 34-week active-controlled extension" 14 : 1145-1154, 2012
31 Haak T, "Initial combination of linagliptin and metformin improves glycaemic control in type 2 diabetes: a randomized, doubleblind, placebo-controlled study" 14 : 565-574, 2012
32 Rosenstock J, "Glucose-lowering activity of the dipeptidyl peptidase-4 inhibitor saxagliptin in drug-naive patients with type 2 diabetes" 10 : 376-386, 2008
33 Jung E, "Gemigliptin, a novel dipeptidyl peptidase-4 inhibitor, exhibits potent anti-glycation properties in vitro and in vivo" 744 : 98-102, 2014
34 Sung-Ho Kim, "Gemigliptin, a novel dipeptidyl peptidase 4 inhibitor: first new anti-diabetic drug in the history of Korean pharmaceutical industry" 대한약학회 36 (36): 1185-1188, 2013
35 Jung E, "Gemigliptin, a dipeptidyl peptidase-4 inhibitor, inhibits retinal pericyte injury in db/db mice and retinal neovascularization in mice with ischemic retinopathy" 1852 : 2618-2629, 2015
36 Jung E, "Gemigliptin improves renal function and attenuates podocyte injury in mice with diabetic nephropathy" 761 : 116-124, 2015
37 Kothny W, "Gallwitz B, Lukashevich V. Improved glycaemic control with vildagliptin added to insulin, with or without metformin, in patients with type 2 diabetes mellitus" 15 : 252-257, 2013
38 Choi HY, "Evaluation of the pharmacokinetics of the DPP-4 inhibitor gemigliptin when coadministered with rosuvastatin or irbesartan to healthy subjects" 31 : 229-241, 2015
39 Kim SE, "Evaluation of the pharmacokinetic interaction between the dipeptidyl peptidase IV inhibitor LC15-0444 and pioglitazone in healthy volunteers" 50 : 17-23, 2012
40 Choi HY, "Evaluation of pharmacokinetic drug interactions between gemigliptin (dipeptidylpeptidase-4 inhibitor) and glimepiride (sulfonylurea) in healthy volunteers" 14 : 165-176, 2014
41 Kadowaki T, "Efficacy, safety and dose-response relationship of teneligliptin, a dipeptidyl peptidase-4 inhibitor, in Japanese patients with type 2 diabetes mellitus" 15 : 810-818, 2013
42 Pi-Sunyer FX, "Efficacy and tolerability of vildagliptin monotherapy in drug-naïve patients with type 2 diabetes" 76 : 132-138, 2007
43 Lukashevich V, "Efficacy and safety of vildagliptin in patients with type 2 diabetes mellitus inadequately controlled with dual combination of metformin and sulphonylurea" 16 : 403-409, 2014
44 Hermansen K, "Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, in patients with type 2diabetes mellitus inadequately controlled on glimepiride alone or on glimepiride and metformin" 9 : 733-745, 2007
45 Raz I, "Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus" 49 : 2564-2571, 2006
46 Charbonnel B, "Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone" 29 : 2638-2643, 2006
47 Rhee EJ, "Efficacy and safety of the dipeptidyl peptidase-4 inhibitor gemigliptin compared with sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone" 15 : 523-530, 2013
48 DeFronzo RA, "Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin in patients with type 2 diabetes and inadequate glycemic control: a randomized, double-blind, placebo-controlled study" 31 : 2315-2317, 2008
49 Hong S, "Efficacy and safety of teneligliptin, a novel dipeptidyl peptidase-4 inhibitor, in Korean patients with type 2 diabetes mellitus:a 24-week multicentre, randomized, double-blind, placebo-controlled phase III trial" 18 : 528-532, 2016
50 Kim MK, "Efficacy and safety of teneligliptin, a dipeptidyl peptidase-4 inhibitor, combined with metformin in Korean patients with type 2 diabetes mellitus: a 16-week, randomized, double-blind, placebo-controlled phase III trial" 17 : 309-312, 2015
51 Vilsboll T, "Efficacy and safety of sitagliptin when added to insulin therapy in patients with type 2 diabetes" 12 : 167-177, 2010
52 Owens DR, "Efficacy and safety of linagliptin in persons with type 2 diabetes inadequately controlled by a combination of metformin and sulphonylurea:a 24-week randomized study" 28 : 1352-1361, 2011
53 Duran-Garcia S, "Efficacy and safety of linagliptin as add-on therapy to basal insulin and metformin in people with Type 2 diabetes" 33 : 926-933, 2016
54 Pratley RE, "Efficacy and safety of initial combination therapy with alogliptin plus metformin versus either as monotherapy in drug-naïve patients with type 2 diabetes:a randomized, double-blind, 6-month study" 16 : 613-621, 2014
55 Nauck MA, "Efficacy and safety of adding the dipeptidyl peptidase-4 inhibitor alogliptin to metformin therapy in patients with type 2 diabetes inadequately controlled with metformin monotherapy: a multicentre, randomised, doubleblind, placebo-controlled study" 63 : 46-55, 2009
56 Marfella R, "Effects of vildagliptin twice daily vs. sitagliptin once daily on 24-hour acute glucose fluctuations" 24 : 79-83, 2010
57 Bosi E, "Effects of vildagliptin on glucose control over 24 weeks in patients with type 2 diabetes inadequately controlled with metformin" 30 : 890-895, 2007
58 Noh YH, "Effects of ketoconazole and rifampicin on the pharmacokinetics of gemigliptin, a dipeptidyl peptidase-IV inhibitor:a crossover drug-drug interaction study in healthy male Korean volunteers" 34 : 1182-1194, 2012
59 Choi HY, "Effects of food on the pharmacokinetics of gemigliptin/metformin sustained-release 50/1,000 mg (25/500mg x 2 tablets) fixeddose combination tablet in healthy male volunteers" 52 : 381-391, 2014
60 Aschner P, "Effect of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes" 29 : 2632-2637, 2006
61 Rosenstock J, "Effect of saxagliptin monotherapy in treatment-naïve patients with type 2 diabetes" 25 : 2401-2411, 2009
62 Barnett AH, "Effect of saxagliptin as add-on therapy in patients with poorly controlled type 2 diabetes on insulin alone or insulin combined with metformin" 28 : 513-523, 2012
63 Shon JH, "Effect of renal impairment and haemodialysis on the pharmacokinetics of gemigliptin (LC15-0444)." 16 : 1028-1031, 2014
64 Del Prato S, "Effect of linagliptin monotherapy on glycaemic control and markers of β-cell function in patients with inadequately controlled type 2 diabetes: a randomized controlled trial" 13 : 258-267, 2011
65 Goldstein BJ, "Effect of initial combination therapy with sitagliptin, a dipeptidyl peptidase-4 inhibitor, and metformin on glycemic control in patients with type 2 diabetes" 30 : 1979-1987, 2007
66 Hwang HJ, "Dipeptidyl petidase-IV inhibitor (gemigliptin) inhibits tunicamycin-induced endoplasmic reticulum stress, apoptosis and inflammation in H9c2 cardiomyocytes" 392 : 1-7, 2014
67 Deacon CF, "Dipeptidyl peptidase-4 inhibitors in the treatment of type 2 diabetes: a comparative review" 13 : 7-18, 2011
68 Choi SH, "Dipeptidyl peptidase-4 inhibition by gemigliptin prevents abnormal vascular remodeling via NF-E2-related factor 2 activation." 73 : 11-19, 2015
69 Min HS, "Dipeptidyl peptidase IV inhibitor protects against renal interstitial fibrosis in a mouse model of ureteral obstruction" 94 : 598-607, 2014
70 Garber AJ, "Consensus statement by the American Association of Clinical Endocrinologists and American College of Endocrinology on the comprehensive type 2 diabetes management algorithm: 2016 executive summary" 22 : 84-113, 2016
71 Deacon CF, "Comparative review of dipeptidyl peptidase-4 inhibitors and sulphonylureas" 18 : 333-347, 2016
72 Rosenstock J, "Alogliptin added to insulin therapy in patients with type 2 diabetes reduces HbA(1C) without causing weight gain or increased hypoglycaemia" 11 : 1145-1152, 2009
73 Kim N, "Absorption, metabolism and excretion of [14C]gemigliptin, a novel dipeptidyl peptidase 4 inhibitor, in humans" 44 : 522-530, 2014
74 Kim Y, "Absorption, distribution, metabolism and excretion of gemigliptin, a novel dipeptidyl peptidase IV inhibitor, in rats" 44 : 627-634, 2014
75 Moses RG, "A randomized controlled trial ofthe efficacy and safety of saxagliptin as add-on therapy in patients with type 2 diabetes and inadequate glycaemic control on metformin plus a sulphonylurea" 16 : 443-450, 2014
76 Yang SJ, "A multicentre, multinational, randomized, placebo-controlled, double-blind, phase 3 trial to evaluate the efficacy and safety of gemigliptin (LC15-0444) in patients with type 2 diabetes" 15 : 410-416, 2013
77 Rhee EJ, "A multicenter, randomized, placebo-controlled, double-blind phase II trial evaluating the optimal dose, efficacy and safety of LC 15-0444 in patients with type 2 diabetes" 12 : 1113-1119, 2010
78 Nabeno M, "A comparative study of the binding modes of recently launched dipeptidyl peptidase IV inhibitors in the active site" 434 : 191-196, 2013