Magnesium ascorbylphosphate incorporated hyaluronic acid/collagen microneedle reinforced by cellulose nanofiber as transdermal delivery system

다국어 초록 (Multilingual Abstract)

Magnesium ascorbyl phosphate (MAP) was included in microneedle(MN) matrix composed of Cellulose nanofiber (CNF), collagen, trehalose, and hyaluronic acid in order to increase the efficiency of transdermal delivery rate. Dissolving various contants (7.5%, 14%, 24.5%) of MAP in microneedle were replicated by casting the mixtures solution on the surface of the silicone molds, centrifuging and drying in room temperature. In the compressive strength test, we confirmed that the 7.5% of MAP was included in MN the mechanical strength of MN was increased but when 14% and 24.5% of MAP was included in MN the mechanical strength of MN was slightly decreased. Even when the high content of MAP in the MN matrix is 14% and 24.5% the mechanical strength was sufficient for skin perforation. The cumulative amount of MAP permeated though skin had positive correlation to the MAP content in the microneedle matrix. This probably the bottom of a MN matrix seems to act as a carrier for the skin permeation of MAP.