Anti-MRSA activity of Epimedoside A (EDA) and synergism between EDA and antibacterial agents against MRSA (methicillin-resistant Staphylococcus aureus) were evaluated by means of Minimal Inhibitory Concentration (MIC). The MICs of EDA against 9 strain...
Anti-MRSA activity of Epimedoside A (EDA) and synergism between EDA and antibacterial agents against MRSA (methicillin-resistant Staphylococcus aureus) were evaluated by means of Minimal Inhibitory Concentration (MIC). The MICs of EDA against 9 strains of MRSA ranged from 3.13 to 6.25 ㎍/ml. Synergism between EDA and vancomycin hydrochloride (VCM) or fosfomycin (FOM) was observed (the fraction inhibitory concentration (FIC) indices were 0.16 and 0.48), while partial synergism was admitted between EDA and other antibacterial agents such as methicillin (DMPPC), cefzonam (CZON), gentamicin (GM), minocycline(MINO) and levofloxacin (LVFX) (the FIC indices were 0.71, 0,73, 0,69,0.65 and 0.58, respectively). These findings suggest that EDA in combination with CCM or FOM may be useful in controlling MRSA infections.