지실 추출물과 Naringin의 주름 개선 효과 = Poncirustrifoliata Immature Fruit Extract and Anti-aging Effect of Naringin

다국어 초록 (Multilingual Abstract)

This study is the result of experiments done to reveal the effect on inhibiting skin creases formation in p photo ageing following UVB irradiation of missing extract (PT_iF) and surface compound naringin. In this study, the anti-inflammatory effects of PT_iF and Naringin were tested on the anti-inflammatory effects of PT_iF in corneal cells induced inflammation with TNF-α/IFN-Flex. PT_iF and naringin showed little toxicity and measured the expression of MMP-1, MMP-2, MMP-9 and MMP-13 mRNA genes associated with collagen decomposition in skin cells, PT_iF extracts and naringin compared to MMP-1, MMP-2, MMP-9 and MMP-13 in order to compare gene manifestations in non-monoprotechnics (MMP-1). In addition, the identification of mRNA manifestations of IL-6 and TNF-α, known as cytokine causing skin irritation, showed that increased IL-6 and TNF-α manifestations by TNF-α+IFN-γ were effectively inhibited by PT_iF extracts and naringin. Based on the above results, PT_iF and the active ingredient, naringin, were demonstrated in the in vitro experiment that inhibits the destructive reaction of collagen tissue caused by UV rays and facilitates collagen production, thereby preventing or mitigating skin wrinkles caused by UV rays.

참고문헌 (Reference)

1 김인덕, "한방원료의 초임계 추출을 이용한 항노화 및 주름개선 효과" 한국생물공학회 23 (23): 529-534, 2008

2 Bernstein EF, "Uitto J Enhanced elastin and fibrillin gene expression in chronically photodamaged skin" 103 : 182-186, 1994

3 Park, J. H, "The Key Medicinal Plants" Shinilbooks 415-417, 2007

4 Kang YH, "Studies on the physiological functionality of pine needle and mugwort extracts" 27 : 978-998, 1995

5 Park YK., "Studies on the effects of Puerariae Flos, Curcumae Radix and Sophorae Radix on the anti oxidation" 16 : 41-53, 2001

6 Park, S. K., "Changes of facial wrinkle after topical application of on emulsion containing medimin A" 25 (25): 23-36, 1999

7 Ick-Dong YOO, "Anti-Skin Aging Effect of Syriacusins from Hibiscus Syriacus on Ultraviolet-Irradiated Human Dermal Fibroblast Cells" 한국응용약물학회 18 (18): 300-307, 2010