A selective glucose sensor based on direct oxidation on a bimetal catalyst with a molecular imprinted polymer

다국어 초록 (Multilingual Abstract)

<P><B>Abstract</B></P> <P>A selective nonenzymatic glucose sensor was developed based on the direct oxidation of glucose on hierarchical CuCo bimetal-coated with a glucose-imprinted polymer (GIP). Glucose was introduced into the GIP composed of Nafion and polyurethane along with aminophenyl boronic acid (APBA), which was formed on the bimetal electrode formed on a screen-printed electrode. The extraction of glucose from the GIP allowed for the selective permeation of glucose into the bimetal electrode surface for oxidation. The GIP-coated bimetal sensor probe was characterized using electrochemical and surface analytical methods. The GIP layer coated on the NaOH pre-treated bimetal electrode exhibited a dynamic range between 1.0µM and 25.0mM with a detection limit of 0.65±0.10µM in phosphate buffer solution (pH 7.4). The anodic responses of uric acid, acetaminophen, dopamine, ascorbic acid, <SMALL>L</SMALL>-cysteine, and other saccharides (monosaccharides: galactose, mannose, fructose, and xylose; disaccharides: sucrose, lactose, and maltose) were not detected using the GIP-coated bimetal sensor. The reliability of the sensor was evaluated by the determination of glucose in artificial and whole blood samples.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Sensor is composed of hierarchical CuCo bimetal-coated with a glucose-imprinted polymer (GIP). </LI> <LI> The proposed sensor selectively detects glucose without interference from other saccharides and other organics. </LI> <LI> The reliability of the sensor was successfully evaluated using artificial and whole blood samples. </LI> </UL> </P>