돼지 난자의 체외성숙과 배아발달 동안 ROS와 항산화제의 영향

다국어 초록 (Multilingual Abstract)

The oocyte undergoes various events during in vitro maturation (IVM) and subsequence development. One of the events is production of reactive oxygen species (ROS) that is a normal process of cell metabolism. But imbalances between ROS production and antioxidant systems induce oxidative stress that negatively affect to mammalian reproductive process. In vitro environments, in vitro matured oocytes have many problems, such as excessive production of ROS and imperfect cytoplasmic maturation. Therefore, in vitro matured oocytes still have lower maturation rates and developmental competence than in vivo matured oocytes. In order to improve the IVM and in vitro culture (IVC) system, antioxidants, vitamins were added to the IVM, IVC medium. Antioxidant supplementation was effective in controlling the production of ROS and it continues to be explored as a potential strategy to overcome mammalian reproductive disorders. Based on these studies, we expect that the use of antioxidants in porcine oocytes could improved maturation and development rates.

목차 (Table of Contents)

• ABSTRACT
• 서론
• ROS
• Superoxide(O2—)
• Hydrogen Peroxide(H2O2)
• Hydroxyl Radical(․OH) (Haber–Weiss)
• 항산화 물질
• Superoxide Dismutase(SOD)
• Glutathione Peroxidase (GPx)
• Catalase(Cat)
• Vitamins
• GSH (Glutathoine)
• Cysteine and Cysteamine (CSH)
• Taurine
• 난자의 체외성숙과 배아발달동안 ROS의 영향
• 난자의 체외성숙과 배아발달에 미치는 항산화제의 효과
• 결론
• REFERENCES