Prostaglandin F2α의 투여가 웅서의 혈중 Testosterone 과 LH 함량 및 부생식기에 미치는 영향 = Effects of Prostaglandin F2α on Plasma Testosterone and LH Levels and Accessory Reproductive Organs in Male Rats

다국어 초록 (Multilingual Abstract)

The present study was undertaken to examine the plasma testosterone concentration of male rats treated with prostaglandin F₂α. In addition, the effects of prostaglandin F₂α on plasma levels of luteinizing hormone (LH), and on the weights of seminal vesicles, ventral prostate and testes were examine in male rats. Rats was injected with 250 ㎍ and 1,000 ㎍ of PGF₂α single for 8 days. The concentrations of testosterone (T) and LH were determined by radioimmunoassay (RIA) after the 8 days treatment period. The results in this experiment were as follows; 1. The concentration of testosterone in plasma of rats treated with 1,000㎍ was 2.73±0.40 ng/㎖. at 14h and 0.92±0.02 ng/㎖ compared to 3.90±0.41 ng/㎖ in control animals and the posttreatment levels were significantly lower than those of pretreatment (p$lt;0.01) at 17 h. However, PGF₂α (250 ng/rat) had no significant effect on plasma testosterone in rats treated with 250 ㎍/day for 8 days. 2. Plasma LH concentration was slightly decreased at 14h but returned to the initial level at 17h. The plasma LH concentration was not affected by the injection of 250 ㎍ or 1,000 ㎍/rat of PGF₂α. 3. Testis weight after treatment with 250 ㎍ and 1,000 ㎍ of PGF₂α was not significant. However, the weights of accessory reproductive glands were greater than in control rats.