Therapeutic Effect of Cyclosporine Administration in a Dog with Pemphigus Foliaceus

다국어 초록 (Multilingual Abstract)

A 3-year-old, intact female Poong-san dog was presented with a 4-month history of erosive, erythematous
dermatitis unresponsive to systemic antibiotics and glucocorticoids. Crust, erosion, and alopecia were noted on the
ear pinnae, bridge of nose, and forelimb. Cytological evaluation of intact pustules showed isolated free-floating rounded
acantholytic keratinocytes admixed with non-degenerated neutrophils and eosinophils. Results of histopathologic
examination revealed the intra-epidermal pustules with predominant neutrophils, less eosinophils, and isolated and
clustered acantholytic cells. A diagnosis of pemphigus foliaceus (PF) was made based on the history, clinical, cytological
and histopathological results. The skin lesions had improved after systemic cyclosporine therapy. This case report
demonstrates that cyclosporine, an immunosuppressive agent, can be used in the management of PF in dogs.

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