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      The Effectiveness of Traditional Korean Medicine for Treating Postoperative Ileus in Gastric Cancer Patients: A Systematic Review and Meta-Analysis

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      https://www.riss.kr/link?id=A108311423

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      다국어 초록 (Multilingual Abstract)

      Objectives: Postoperative ileus (POI) is a common impairment of gastrointestinal motility and causes a delay in postoperative recovery, as well as an increased length of hospital stay, but no single strategy has a significant recuperative effect on PO...

      Objectives: Postoperative ileus (POI) is a common impairment of gastrointestinal motility and causes a delay in postoperative recovery, as well as an increased length of hospital stay, but no single strategy has a significant recuperative effect on POI. Studies of traditional Korean medicine (TKM) have reported improvements in bowel function after surgery. The aim of this systematic review was to assess the effectiveness of TKM on postoperative ileus in gastric cancer patients.
      Methods: We used six databases to search for studies published from January 1, 2007, until May 11, 2022. The included studies were those reporting gastric cancer patients who received TKM treatment after gastrectomy through indicators related to POI.
      Results: The search identified 27 RCTs that used herbal medicine (Daegeonjung-tang and Gami-leejoongtang), herbal medicine combined with acupuncture (Sama-tang, Gumiseunggi-tang, Daeseunggi-tang, and Insam-tang), acupuncture, acupuncture and moxibustion, electroacupuncture, warm needling, transcutaneous electroacupuncture (TEA), low-frequency electrical acupoint stimulation (LEAS), moxibustion, auricular acupressure, and ST-36 acupoint injection with neostigmine as treatments for POI. The time to first flatus was shortened by herbal medicine combined with warm needling (Sama-tang, Gumiseunggi-tang, Daeseunggi-tang, and Insam-tang), acupuncture, electroacupuncture, warm needling, TEA, moxibustion, auricular acupressure, and ​ST-36 acupoint injection with neostigmine (p<0.00001). The time to the first defecation decreased significantly in response to the herbal medicine combined with warm needling (Sama-tang, Gumiseunggi-tang, Daeseunggi-tang, and Insam-tang), acupuncture, electroacupuncture, warm needling, TEA, moxibustion, auricular acupressure, and ST-36 acupoint injection with neostigmine (p<0.00001). No serious adverse events occurred.
      Conclusions: TKM could be a promising option for preventing and resolving POI in gastric cancer patients after gastrectomy.

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      참고문헌 (Reference) 논문관계도

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      2 You X, "Zusanli(ST36)Acupoint Injection with Neostigmine for Paralytic Postoperative Ileus Following Radical Gastrectomy for Gastric Cancer : a randomized clinical trial" 9 (9): 2266-2274, 2018

      3 Hulzinga JD, "W/kit gene Required for Interstitial Cells of Cajal and for Intestinal Pacemaker Activity" 373 (373): 347-349, 1995

      4 Chen KB, "Transcutaneous Electroacupuncture Alleviates Postoperative Ileus after Gastrectomy : a randomized clinical trial" 10 (10): 13-, 2018

      5 Ye GD, "The Value of Auricular Acupressure in Promoting the Rapid Recovery of Gastrointestinal Function in Patients with Gastric Cancer after Surgery" 56 (56): 153-156, 2018

      6 Huang WJ, "The Effectiveness of Auricular Pressure on Gastrointestinal Function Recovery of Postoperative Patients with Gastric Cancer" 14 (14): 827-829, 2014

      7 Guo JH, "The Effect of Renshen Decoction Combined with Acupuncture on the Recovery of Gastrointestinal Function in Patients with Gastric Cancer after Operation" 19 (19): 120-122, 2021

      8 Liedman B, "Symptoms after Total Gastrectomy on Food Intake, Body Composition, Bone Metabolism, and Quality of Life in Gastric Cancer Patients—Is Reconstruction with a Reservoir Worthwhile?" 15 (15): 677-682, 1999

      9 Korenaga D, "Results of Resection of Gastric Cancer Extending to Adjacent Organs" 75 (75): 12-15, 1988

      10 Artinyan A, "Prolonged Postoperative Ileus-Definition, Risk factors, and Predictors after Surgery" 32 (32): 1495-1500, 2008

      1 한가진 ; 장명웅 ; 성신 ; 김성수, "가미도홍사물탕 약욕요법 이후 호전된 항암화학요법 유발 수족증후군 1례" 대한한방내과학회 39 (39): 259-267, 2018

      2 You X, "Zusanli(ST36)Acupoint Injection with Neostigmine for Paralytic Postoperative Ileus Following Radical Gastrectomy for Gastric Cancer : a randomized clinical trial" 9 (9): 2266-2274, 2018

      3 Hulzinga JD, "W/kit gene Required for Interstitial Cells of Cajal and for Intestinal Pacemaker Activity" 373 (373): 347-349, 1995

      4 Chen KB, "Transcutaneous Electroacupuncture Alleviates Postoperative Ileus after Gastrectomy : a randomized clinical trial" 10 (10): 13-, 2018

      5 Ye GD, "The Value of Auricular Acupressure in Promoting the Rapid Recovery of Gastrointestinal Function in Patients with Gastric Cancer after Surgery" 56 (56): 153-156, 2018

      6 Huang WJ, "The Effectiveness of Auricular Pressure on Gastrointestinal Function Recovery of Postoperative Patients with Gastric Cancer" 14 (14): 827-829, 2014

      7 Guo JH, "The Effect of Renshen Decoction Combined with Acupuncture on the Recovery of Gastrointestinal Function in Patients with Gastric Cancer after Operation" 19 (19): 120-122, 2021

      8 Liedman B, "Symptoms after Total Gastrectomy on Food Intake, Body Composition, Bone Metabolism, and Quality of Life in Gastric Cancer Patients—Is Reconstruction with a Reservoir Worthwhile?" 15 (15): 677-682, 1999

      9 Korenaga D, "Results of Resection of Gastric Cancer Extending to Adjacent Organs" 75 (75): 12-15, 1988

      10 Artinyan A, "Prolonged Postoperative Ileus-Definition, Risk factors, and Predictors after Surgery" 32 (32): 1495-1500, 2008

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      21 Kehlet H, "Fast-track colorectal surgery" 371 (371): 791-793, 2008

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      23 Ding YQ, "Electroacupuncture treatment in gastric cancer patients : a RCT research for enhanced recovery after surgery" 37 (37): 107-110, 2021

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      27 Wu J, "Effects of Warm Acupuncture Combined with Acupoint Massage on Serum Gastrin Motilin Level and Gastrointestinal Function in Patients with Gastric Cancer after Operation" 34 (34): 232-235, 2021

      28 Zhou X, "Effects of Transcutaneous Electrical Acupoint Stimulation(TEAS)on Postoperative Recovery in Patients with Gastric Cancer : a randomized controlled trial" 13 : 1449-1458, 2021

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      35 Chen QQ, "Effect of Simotang Oral Liquid and Warm Acupuncture on Gastrointestinal Function and Peripheral Blood Leukocyte after Operation in Patients with Gastric Cancer" 3 (3): 49-58, 2015

      36 Zhang YW, "Effect of Moxibustion on Recovery of Gastrointestinal Motility Function after Gastric Cancer Operation" 8 : 795-796, 2014

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      55 Liu Y, "Acupuncture and Related Therapies for Treatment of Postoperative Ileus in Colorectal Cancer : a systematic review and meta-analysis of randomized controlled trials" 22 : 1-18, 2018

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      57 Deng J, "Acupuncture Ameliorates Postoperative Ileus via IL-6-miR-19a-KIT Axis to Protect Interstitial Cells of Cajal" 45 (45): 737-755, 2017

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