구제역 : 원인체의 특성, 국내, 외 발생 상황 및 예방대책 = Foot and Mouth Disease : Etiology, Epidemiology and Control Measures

다국어 초록 (Multilingual Abstract)

Foot and mouth disease (FMD) is highly infectious disease of cloven-hoofed animals, particularly cattle, sheep, pigs and goats. Also, it is the most important animal pathogen on the global scale because of the potential for rapid and extensive spread through susceptible animal populations. Outbreak can lead to formidable economic consequence for domestic livestock production and international trade. FMD is caused by FMD virus which is a small, non-enveloped,positive-sense RNA virus belonging to the genus Aphthovirus within the family Picornaviridae . There are seven immunologically distinct serotypes; O, A, C, SAT (Southern African Territories) 1, SAT 2, SAT 3 and Asia 1 and a diverse antigenic spectrum of virus strains within each serotype. Characteristic lesion of FMD is the formation of vesicles in the mucosal membranes of mouth, muzzle, foot, and teats.
Nowadays, many developed countries have maintained FMD-free as a result of eradication efforts. However, outbreaks of FMD have occurred in several countries,even in Europe, and it is still endemic in Africa, the Middle East, Asia, and South America. Last year, three outbreaks of FMD occurred in our country. Last outbreak reported in November, 2010 induced the enormous social and economical impacts. Culling of infected animals, movement control, and vaccination are the major control measures of FMD. To control the disease, each country has their own strategies based on the current situation of FMD in their country. Therefore, I would like to discuss the causative agent, epidemiological properties and control measures of FMD in this paper.

참고문헌 (Reference)

1 배유찬, "국내 발생 구제역 및 구제역 유사질병 도감" National Veterinary Research & Quarantine Service, MAF 2003

2 Ministry for Food, Agriculture, Forestry and Fisheries, "구제역백서" National Veterinary Research & Quarantine Service 2003

3 Paiba GA, "Validation of a foot-and-mouth disease antibody screening solidphase competition ELISA (SPCE)" 115 : 145-158, 2004

4 서정향, "Use of a portable real-time reverse transcriptase-polymerase chain reaction assay for rapid detection of foot-and-mouth disease virus" 220 (220): 1636-1642, 200206

5 Sutmoller P, "Unapparent foot and mouth disease infection (sub-clinical infections and carriers): implications for control" 21 : 519-529, 2002

6 Brown F, "The use of acetylethyleneimine in the production of inactivated foot-and-mouth disease vaccines" 61 : 337-344, 1963

7 Cottral GE, "The survival of foot-and-mouth disease virus in cured and uncured meat" 21 : 288-297, 1960

8 Laporte J, "The structure of foot-and-mouth disease virus protein" 4 : 631-634, 1969

9 Thomson GR, "The role of carriers in the transmission of foot and mouth disease" International Committee or to Regional Commissions 87-103, 1996

10 Krystynak RH, "The potential economic impact of an outbreak of foot-and-mouth disease in Canada" 28 : 523-527, 1987

11 Burrows R, "The pathogenesis of natural and simulated natural foot-and-mouth disease infection in cattle" 91 : 599-609, 1981

12 Alexandersen S, "The pathogenesis and diagnosis of foot-and-mouth disease" 129 : 1-36, 2003

13 De Diego M, "The non-structural polyprotein 3ABC of foot-and-mouth disease virus as a diagnostic antigen in ELISA to differentiate infected from vaccinated cattle" 142 : 2021-2033, 1997

14 Bahnemann HG, "The inactivation of foot-and-mouth disease virus by ethylenimine and propylenimine" 20 : 356-360, 1972

15 Sanson RL, "The epidemiology of foot-and-mouth disease: implications for New Zealand" 42 : 41-53, 1994

16 Thomson GR, "The epidemiology and control of foot-and-mouth disease in sub-Saharan Africa, in Foot-and-mouth disease: control strategies" Elsevier 125-134, 2003

17 Condy JB, "The duration of the foot-and-mouth disease virus carrier state in African buffalo (i) in the individual animal and (ii) in a free-living herd" 8 : 259-265, 1985

18 Park JH, "The condition for air-borne transmission of foot-and-mouth disease" 32 : 205-212, 2008

19 Ferris NP, "The World Reference Laboratory for Foot and Mouth Disease: a review of thirty-three years of activity (1958- 1991)" 11 : 657-684, 1992

20 Sharma SK, "Studies on foot and mouth disease in sheep with special reference to distribution of the virus and carrier status" 1 : 156-157, 1978

21 Mahul O, "Simulated economic consequences of footand- mouth disease epidemics and their public control in France" 47 : 23-38, 2000

22 Ferris NP, "Routine application of enzyme-linked immunosorbent assay in comparison with complement fixation for the diagnosis of foot-and-mouth and swine vesicular diseases" 16 : 201-209, 1988

23 Park JH, "Resistance of footand- mouth disease virus in various environments" 33 : 197-204, 2009

24 Wijnker JJ, "Removal of foot-and-mouth disease virus infectivity in salted natural casings by minor adaptation of standardized industrial procedures" 115 : 214-219, 2007

25 Donaldson AI, "Relative risks of the uncontrollable (airborne) spread of FMD by different species" 148 : 602-604, 2001

26 Donaldson AI, "Relative resistance of pigs to infection by natural aerosols of FMD virus" 148 : 600-602, 2001

27 Rowlands DJ, "Relationship of the antigenic structure of foot-and-mouth disease virus to the process of infection" 13 : 85-93, 1971

28 Sellers RF, "Recovery of virus from bulls affected with foot-and-mouth disease" 83 : 303-, 1968

29 Vangrysperre W, "Rapid and sensitive polymerase chain reaction based detection and typing of foot-and-mouth disease virus in clinical samples and cell culture isolates, combined with a simultaneous differentiation with other genomically and/or symptomatically related viruses" 141 : 331-344, 1996

30 Golding SM, "Radial immuno-diffusion and serum-neutralisation techniques for the assay of antibodies to swine vesicular disease" 20 : 142-147, 1976

31 Sellers RF, "Quantitative aspects of the spread of foot and mouth disease" 41 : 431-439, 1971

32 Paton DJ, "Qualitative assessment of the commodity risk for spread of foot-and-mouth disease associated with international trade in deboned beef" 57 : 115-134, 2010

33 Reid SM, "Primary diagnosis of foot-and-mouth disease by reverse transcription polymerase chain reaction" 89 : 167-176, 2000

34 Hutber AM, "Predicting the level of herd infection for outbreaks of foot-and-mouth disease in vaccinated herds" 122 : 539-544, 1999

35 Lee SH, "Pathology and viral distributions of the porcinophilic foot-andmouth disease virus strain (O/Taiwan/97) in experimentally infected pigs" 56 : 189-201, 2009

36 World Organisation for Animal Health, "Office International des Epizooties. Foot and mouth disease, Paris, France"

37 Bastos AD, "Natural transmission of foot-and-mouth disease virus between African buffalo (Syncerus caffer) and impala (Aepyceros melampus) in the Kruger National Park, South Africa" 124 : 591-598, 2000

38 World Organisation for Animal Health, "Manual of diagnostic tests and vaccines for terrestrial animals: mammals, birds and bees" Office international des epizooties 2008

39 Mahul O, "Irreversible decision making in contagious animal disease control under uncertainty: an illustration using FMD in Brittany" 26 : 39-58, 1999

40 Donaldson AI, "Infection of cattle by airborne foot-and-mouth disease virus: minimal doses with O1 and SAT 2 strains" 43 : 339-346, 1987

41 Bachrach HL, "Inactivation of foot-and-mouth disease virus by pH and temperature changes and by formaldehyde" 95 : 147-152, 1957

42 Chou CC, "Inactivation and degradation of O Taiwan97 foot-and-mouth disease virus in pork sausage processing" 21 : 737-742, 2004

43 Bergmann IE, "Improvement of a serodiagnostic strategy for foot-andmouth disease virus surveillance in cattle under systematic vaccination: a combined system of an indirect ELISA-3ABC with an enzyme- linked immunoelectrotransfer blot assay" 145 : 473-489, 2000

44 Sutmoller P, "Importation of beef from countries infected with foot and mouth disease: a review of risk mitigation measures" 20 : 715-722, 2001

45 Shaw AE, "Implementation of a one-step real-time RT-PCR protocol for diagnosis of foot-and-mouth disease" 143 : 81-85, 2007

46 Bachrach HL, "Immune and antibody responses to an isolated capsid protein of foot-and-mouth disease virus" 115 : 1636-1641, 1975

47 Kitching RP, "Identification of foot and mouth disease virus carrier and subclinically infected animals and differentiation from vaccinated animals" 21 : 531-538, 2002

48 McVicar JW, "Growth of foot-and-mouth disease virus in the upper respiratory tract of non-immunized, vaccinated, and recovered cattle after intranasal inoculation" 76 : 467-481, 1976

49 Capstick PB, "Growth of a cloned strain of hamster kidney cells in suspended cultures and their susceptibility to the virus of foot-and-mouth disease" 195 : 1163-1164, 1962

50 Beard CW, "Genetic determinants of altered virulence of Taiwanese foot-and-mouth disease virus" 74 : 987-991, 2000

51 Kitching RP, "Future research on foot and mouth disease" 21 : 885-889, 2002

52 Cox BF, "Further studies on the survival of foot-and-mouth disease virus in meat" 22 : 224-, 1961

53 Alonso A, "Footand- mouth disease virus typing by complement fixation and enzyme-linked immunosorbent assay using monovalent and polyvalent antisera" 4 : 249-253, 1992

54 Kaleta EF, "Foot-and-mouth disease: susceptibility of domestic poultry and free-living birds to infection and to disease--a review of the historical and current literature concerning the role of birds in spread of foot-and-mouth disease viruses" 109 : 391-399, 2002

55 Pharo HJ, "Foot-and-mouth disease: an assessment of the risks facing New Zealand" 50 : 46-55, 2002

56 Sobrino F, "Foot-and-mouth disease: a long known virus, but a current threat" 32 : 1-30, 2000

57 Ryan E, "Foot-and-mouth disease virus concentrations in products of animal origin" 55 : 89-98, 2008

58 Gibbs EP, "Foot-and-mouth disease in British deer: transmission of virus to cattle, sheep and deer" 96 : 558-563, 1975

59 Grubman MJ, "Foot-and-mouth disease" 2 : 465-493, 2004

60 United States Department of Agriculture (USDA), "Foot and mouth disease: Sources of outbreaks and hazard categorization of modes of virus transmission" USDA, APHIS, VS 1994

61 Timoney JF, "Foot and mouth disease, in Hagan and Bruner's microbiology and infectious diseases of domestic animals" Cornell University Press 647-667, 1988

62 Rodriguez LL, "Foot and mouth disease virus vaccines" 27 (27): D90-D94, 2009

63 Davies G, "Foot and mouth disease" 73 : 195-199, 2002

64 Doel TR, "FMD vaccines" 91 : 81-99, 2003

65 Cox SJ, "Experimental evaluation of foot-and-mouth disease vaccines for emergency use in ruminants and pigs: a review" 40 : 13-, 2009

66 Burrows R, "Excretion of foot-and-mouth disease virus prior to the development of lesions" 82 : 387-388, 1968

67 Reid SM, "Evaluation of automated RT-PCR to accelerate the laboratory diagnosis of foot-and-mouth disease virus" 107 : 129-139, 2003

68 Hamblin C, "Enzyme-linked immunosorbent assay (ELISA) for the detection of antibodies against foot-and-mouth disease virus. III. Evaluation of antibodies af ter infection and vaccination" 99 : 733-744, 1987

69 Doel TR, "Emergency vaccination against foot-and-mouth disease: rate of development of immunity and its implications for the carrier state" 12 : 592-600, 1994

70 Belsham GJ, "Distinctive features of foot-and-mouth disease virus, a member of the picornavirus family; aspects of virus protein synthesis, protein processing and structure" 60 : 241-260, 1993

71 Sørensen KJ, "Differentiation of infection from vaccination in foot-and-mouth disease by the detection of antibodies to the non-structural proteins 3D, 3AB and 3ABC in ELISA using antigens expressed in baculovirus" 143 : 1461-1476, 1998

72 Mackay DK, "Differentiating infection from vaccination in foot-and-mouth disease using a panel of recombinant, nonstructural proteins in ELISA" 16 : 446-459, 1998

73 Ferris NP, "Development and laboratory validation of a lateral flow device for the detection of foot-and-mouth disease virus in clinical samples" 155 : 10-17, 2009

74 Roeder PL, "Detection and typing of foot-andmouth disease virus by enzyme-linked immunosorbent assay: a sensitive, rapid and reliable technique for primary diagnosis" 43 : 225-232, 1987

75 Sutmoller P, "Control and eradication of foot-and-mouth disease" 91 : 101-144, 2003

76 Kleid DG, "Cloned viral protein vaccine for foot-and-mouth disease: responses in cattle and swine" 214 : 1125-1129, 1981

77 Kitching RP, "Clinical variation in foot and mouth disease: pigs" 21 : 513-518, 2002

78 Kitching RP, "Clinical variation in foot and mouth disease: cattle" 21 : 499-504, 2002

79 Moonen P, "Carriers of foot-and-mouth disease virus: a review" 22 : 193-197, 2000

80 Alexandersen S, "Aspects of the persistence of foot-and-mouth disease virus in animals--the carrier problem" 4 : 1099-1110, 2002

81 Garner MG, "An evaluation of alternate control strategies for foot-and-mouth disease in Australia - a regional approach" 23 : 9-32, 1995

82 Gloster J, "Airborne spread of foot-and-mouth disease--model intercomparison" 183 : 278-286, 2010

83 Mackay DK, "A solidphase competition ELISA for measuring antibody to foot-andmouth disease virus" 97 : 33-48, 2001

84 Chénard G, "A solidphase blocking ELISA for detection of type O foot-and-mouth disease virus antibodies suitable for mass serology" 107 : 89-98, 2003

85 Morris CA, "A review of genetic resistance to disease in Bos taurus cattle" 174 : 481-491, 2007

86 Hamblin C, "A new enzyme-linked immunosorbent assay (ELISA) for the detection of antibodies against foot-and-mouth disease virus. I. Development and method of ELISA" 93 : 115-121, 1986

87 Berentsen PBM, "A dynamic model for cost-benefit analyses of foot-and-mouth disease control strategies" 12 : 229-243, 1992