amhwasan promoting the circulating of Qi (氣,) was tested for the effects on acetylcholine esterase and monoamine oxidase activities and lipid peroxidation for studying the effects of dementia in rat's brain.
In vitro, levels of lipid peroxide and a...
amhwasan promoting the circulating of Qi (氣,) was tested for the effects on acetylcholine esterase and monoamine oxidase activities and lipid peroxidation for studying the effects of dementia in rat's brain.
In vitro, levels of lipid peroxide and acetylcholine esterase activies in tissues of brain were proportionally decreased to concentration of extracts prepared from Samhwasan.
In vivo, after extract of Samhwasan was administered to the rat, levels of lipid peroxide was decreased according to treatment days and dose. And, enzyme activities and ratio of type conversion of xanthine oxidase were decreased, too. Also, enzyme activities of acetylcholine esterase were lowered. But, there was not special changes in ALT and AST activites.
These results suggest that Samhwasan might have an effect on treatment of dementia according to decreasing the activities of acetylcholine esterase and lipid peroxide in brain.