마우스 및 랫드에서 자양강장제 황제공진보의 단회투여독성시험 = Single Dose Toxicity Study of Hwangjaegongjinbo, an Invigorator in Mice and Rats

다국어 초록 (Multilingual Abstract)

The single dose toxicity of Hwangjaegongjinbo, an invigorator, developed by Korea Medical Science Institute was evaluated in ICR mice and Sprague-Dawley rats. The aqueous solution of freeze-dried powder of Hwangjaegongjinbo or its original solution was once administrated orally to both sexes of mice and rats at dose of 2000 mg/kg, the recommended upper limit dose for acute toxicity. Water was administered to another group as control. After single administration, signs of toxicity were observed every hour for the first 6 hours and every day for 14 days. Neither significant toxic signs nor death was observed during the observation period. In addition, no pathological changes were noticed in macroscopic examination at necropsy in those treated group. These results indicated that LD_(50) of Hwangjaegongjinbo is greater than 2000 mg/kg in ICR mice and Sprague-Dawley rats.