카페인이 HRV에 미치는 영향과 내관 자침의 효과에 대한 예비연구 : 무작위 이중맹검시험 = Short Time Effect of Caffeine on Heart Rate Variability and the Effect of Acupuncture at Neiguan (PC6): A Randomized Double Blind Pilot Study

다국어 초록 (Multilingual Abstract)

Objectives : This study was to investigate the short time effect of caffeine on heart rate variability(HRV) and the effect of Neiguan(PC6) acupuncture stimulation on HRV. Methods : 27 healthy adult volunteers were randomly allocated to two groups: Neiguan group (N=13) or placebo group (N=14). The study was carried out under a randomized double-blinded placebo-controlled trial method. Each group orally received the same tablets with 200 mg caffeine. After 1 hour, acupuncture was applied to the Neiguan(PC6) points for the Neiguan group, and for the placebo group was applied to a non-acupuncture point. Both groups were estimated with HRV 3 times, before and after caffeine ingestion, 20 minutes after acupuncture stimulation. Results : After taking caffeine, pulse rate, mean-HRV, and pNN50(the proportion derived by dividing NN50 by the total number of NN intervals) decreased, SDNN(standard deviation of all normal-to-normal (NN) intervals), RMSSD (the root square of successive differences), TP log, HF(high frequency), and HRV index was increased. There were significant changes to the autonomic nervous system after taking caffeine. There were no significant differences between the two groups after acupuncture at Neiguan. Conclusion : Caffeine could induce general activation of the autonomic nervous system. Neiguan acupuncture stimulation may not have significant influence on the autonomic nervous system.

참고문헌 (Reference)

1 일본 자율신경 기능학회, "자율신경기능진단" 군자출판사 172-186, 2007

2 Katzung BG, "임상약리학" 대한의학서적 566-567, 2002

3 장보형, "이침 요법이 정신적 스트레스를 가한 성인의 심박변이도에 미치는 영향" 대한침구학회 22 (22): 173-180, 2005

4 최창민, 정재한, 이승엽, 최원우, 홍진우, 박성욱, 정우상, 문상관, 박정미, 고창남, 조기호, 김영석, 배형섭, 선종주, 김석민, "우황청심원이 정상인의 심박변이도에 미치는 영향" 대한한방내과학회 28 (28): 717-726, 2007

5 전중선, "심박변동의 Power spectrum분석에 의한 정상 성인의 자율신경기능 평가" 21 (21): 928-935, 1997

6 정인태, "만성 두통 환자에 대한 침치료가 심박변이도에 미치는 영향" 대한침구학회 22 (22): 105-112, 2005

7 양창섭, "마황복용이 정상성인의 체중 감소와 심박변이도에 미치는 영향에 관한 예비 연구: 무작위배정 이중맹검시험" 대한한방내과학회 27 (27): 836-844, 2006

8 한성수, "근거 중심 의학(EBM)에 바탕을 둔 임상시험(Clinical Trial)에서 침 치료 문제점과 개선 방안에 대하여" 대한침구학회 23 (23): 1-8, 2006

9 안영기, "경혈학총서" 성보사 488-489, 2000

10 설현, "肩井穴 黃連解毒湯藥鍼이 심박변이율(HRV)에 미치는 영향" 대한침구학회 21 (21): 37-50, 2004

11 김정신, "少府(HT8) 刺針이 정신적 스트레스를 가한 성인의 심박변이도에 미치는 영향" 대한침구학회 21 (21): 227-240, 2004

12 Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability, "standards of measurement, physiological interpretation and clinical use" 93 (93): 1043-1065, 1996

13 Malliani A, "Power spectrum analysis of heart rate variabillity: a tool to explore neural regulatory mechanisms" 71 (71): 1-2, 1994

14 Kamath MV, Fallen, "Power spectral analysis of heart rate variability: a noninvasive signature of cardiac autonomic function" 21 (21): 245-311, 1993

15 LaGow B., "PDR for herbal medicine 2004" Thomson PDR 213-216, 2004

16 Cowan MJ., "Measurement of heart rate variability" 17 (17): 32-48, 1995

17 Cowan MJ., "Measurement of heart rate variability" 17 (17): 32-48, 1995

18 Li Z, "Effects of acupunture on heart rate variabillity in normal subjects under fatigue and non-fatigue state" 94 (94): 633-636, 2005

19 Khan MG., "Caffeine and the Heart" Encyclopedia of Heart Diseases 189-191, 2006

20 Lane JD, "Caffeine affects cardiovascular responses to stress" 22 (22): 648-655, 1985

21 Lane JD, "Caffeine affects cardiovascular and neuroendocrine activation at work and home" 64 (64): 595-603, 2002

22 Bruns RF, "Adenosine Receptor Subtypes: Binding Studies. Topics and Perspective in Adenosine Research" Springer 59-73, 1987

23 Sondermeijer HP, "Acute effects of caffeine on heart rate variability" 90 (90): 906-907, 2002

24 Waring WS, "Acute caffeine intake influences central more than peripheral blood pressure in young adults" 16 (16): 919-924, 2003

25 Middlekauff HR, "Acupuncture inhibits sympathetic activation during mental stress in advanced heart failure patients" 8 (8): 399-406, 2002