<P>We developed a novel gravimetric immunoassay for sensitive detection of multiple protein biomarkers using silicon microcantilever arrays and multifunctional hybrid nanoparticles. Magnetic–photocatalytic hybrid nanoparticles with a highl...
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https://www.riss.kr/link?id=A107615113
2012
-
SCOPUS,SCIE
학술저널
4375-4381(7쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
<P>We developed a novel gravimetric immunoassay for sensitive detection of multiple protein biomarkers using silicon microcantilever arrays and multifunctional hybrid nanoparticles. Magnetic–photocatalytic hybrid nanoparticles with a highl...
<P>We developed a novel gravimetric immunoassay for sensitive detection of multiple protein biomarkers using silicon microcantilever arrays and multifunctional hybrid nanoparticles. Magnetic–photocatalytic hybrid nanoparticles with a highly crystalline TiO<SUB>2</SUB> shell were synthesized using a solvothermal reaction without a calcination process. After functionalizing the hybrid nanoparticles and silicon cantilevers with antibodies, the nanoparticles were used to magnetically separate target biomarkers from human serum. Frequency changes of the microcantilevers due to the binding of the nanoparticles were measured using a dip-and-dry method. Frequency changes were further amplified using a photocatalytic silver reduction reaction. Several biomarkers, including interleukin-6, interferon-γ, and alpha-fetoprotein, were selectively detected using arrays of eight silicon microcantilevers. The detection limit of this assay was ∼0.1 pg/mL, which is superior to the clinical threshold of the biomarkers.</P><P><B>Graphic Abstract</B>
<IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2012/ancac3.2012.6.issue-5/nn301071c/production/images/medium/nn-2012-01071c_0007.gif'></P>
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