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https://www.riss.kr/link?id=A19741314
2002
-
500
KCI등재
학술저널
36-45(10쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
Objective: Overall incidence of stroke is uniformly higher in men than in women, and rare especially in women during the reproductive stage. A number of studies have demonstrated the reduced infarct size upon administration of estrogen to ovariectomiz...
Objective: Overall incidence of stroke is uniformly higher in men than in women, and rare especially in women during the reproductive stage. A number of studies have demonstrated the reduced infarct size upon administration of estrogen to ovariectomized females in ischemic brain injury models. Design: We aimed to examine the potential neuroprotective effects of 17 beta-estradiol on the cerebral infarct size and then on the apoptotic mechanism after the completion of 2-hour occlusion of middle cerebral artery (MCA) and 24-hour reperfusion. Results: The ischemic zone with cerebral infarct was consistently observed in the cortex and striatum of the left hemisphere at 24 hours of reperfusion after the completion of 2-hour occlusion of left MCA. The infarct area and volume were significantly reduced, when rats received 4 and 10 mg/kg 17 β-estradiol intraperitoneally 24 hours before and 5 min after 2-hour ischemia. Samples from the regions corresponding to the penumbra showed markedly reduced Bcl-2 protein level and, in contrast, high levels of Bax protein and cytochrome c release. Both increased Bax and cytochrome c were significantly reduced, and decreased Bcl-2 protein was markedly restored by 17 β-estradiol. 17 β-estradiol(10-1-10-5M) potently scavenged hydroxyl radicals and inhibited intracellular hydrogen peroxide production. Conclusion: 17 β-estradiol treatments decrease ischemic brain infarction in association with inhibition of apoptotic cell death.
Isoflavone 이 골모세포의 Alkaline Phosphatase 의 활성도에 미치는 영향
한국 폐경여성의 호르몬 대체 요법에 대한 인지도와 수용성에 대한 연구 - 폐경과 호르몬 대체요법에 대한 한국 갤럽 역학연구 조사 결과
폐경기 증후군 환자에서 홍삼 복방 제품의 임상적 유용성
이소플라본 섭취수준이 폐경기 여성의 혈청내 지질 패턴 및 골다공증 예방에 미치는 영향