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      In vitro bioaccessibility of added folic acid in commercially available baby foods formulated with milk and milk products

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      https://www.riss.kr/link?id=A106479936

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      다국어 초록 (Multilingual Abstract)

      Milk contains a certain amount of folate bindingproteins. The binding capacity varies in acidic conditionsand affects the bioavailability of folic acid. Folic acid iscommonly added into baby foods to ensure adequate intakeof infants. The aim of this study was to determine thebioaccessibility of added folic acid in baby foods formulatedwith milk and milk products under different gastricpH values by an in vitro digestive system. The bioaccessibilityof folic acid ranged between 56–71 and 35–49% ininfant formula samples, between 59–78 and 31–67% incereal-based baby foods, and between 42–67 and 38–57%in follow-on baby milk at gastric pH 1.5 and pH 4,respectively. Our results demonstrate that the bioaccesibilityof folic acid that is added to baby food is affected bygastric pH. Therefore, it was observed that the bioaccesibilityof folic acid was lower in the higher gastric pH.
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      Milk contains a certain amount of folate bindingproteins. The binding capacity varies in acidic conditionsand affects the bioavailability of folic acid. Folic acid iscommonly added into baby foods to ensure adequate intakeof infants. The aim of this s...

      Milk contains a certain amount of folate bindingproteins. The binding capacity varies in acidic conditionsand affects the bioavailability of folic acid. Folic acid iscommonly added into baby foods to ensure adequate intakeof infants. The aim of this study was to determine thebioaccessibility of added folic acid in baby foods formulatedwith milk and milk products under different gastricpH values by an in vitro digestive system. The bioaccessibilityof folic acid ranged between 56–71 and 35–49% ininfant formula samples, between 59–78 and 31–67% incereal-based baby foods, and between 42–67 and 38–57%in follow-on baby milk at gastric pH 1.5 and pH 4,respectively. Our results demonstrate that the bioaccesibilityof folic acid that is added to baby food is affected bygastric pH. Therefore, it was observed that the bioaccesibilityof folic acid was lower in the higher gastric pH.

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      참고문헌 (Reference)

      1 Ball GFM, Folate, "Vitamins: Their Role in the Human. 1" Blackwell Publishing Ltd 348-349, 2004

      2 Elliot CM, "Vitamin B: New Research, 1" Nova Biomedical Books, Nova Science Publishers Inc 39-57, 2008

      3 Menard O, "Validation of a new in vitro dynamic system to simulate infant digestion" 145 : 1039-1045, 2014

      4 USDA, "United States Department of Agriculture. USDA Food Composition Databases"

      5 Eichholzer M, "The role of folate, antioxidant vitamins and other constituents in fruits and vegetables in the prevention of cardiovascular disease: the epidemiological evidence" 71 : 5-17, 2001

      6 Salter DN, "The preparation and properties of folate binding protein from cow’s milk" 193 : 469-476, 1981

      7 Verwei M, "The effect of folate-binding proteins on bioavailability of folate from milk products" 16 : 307-310, 2005

      8 Campos-Giménez E, "The contribution of minor folates to the total vitamin B9 content of Infant formula and clinical nutrition products" 249 : 91-97, 2018

      9 Verwei M, "The binding of folic acid and 5-methyltetrahydrofolate to folate-binding proteins during gastric passage differs in a dynamic in vitro gastrointestinal model" 134 : 31-37, 2004

      10 Bourlieu C, "Specificity of infant digestive conditions: some clues for developing relevant in vitro models" 54 : 1427-1457, 2014

      1 Ball GFM, Folate, "Vitamins: Their Role in the Human. 1" Blackwell Publishing Ltd 348-349, 2004

      2 Elliot CM, "Vitamin B: New Research, 1" Nova Biomedical Books, Nova Science Publishers Inc 39-57, 2008

      3 Menard O, "Validation of a new in vitro dynamic system to simulate infant digestion" 145 : 1039-1045, 2014

      4 USDA, "United States Department of Agriculture. USDA Food Composition Databases"

      5 Eichholzer M, "The role of folate, antioxidant vitamins and other constituents in fruits and vegetables in the prevention of cardiovascular disease: the epidemiological evidence" 71 : 5-17, 2001

      6 Salter DN, "The preparation and properties of folate binding protein from cow’s milk" 193 : 469-476, 1981

      7 Verwei M, "The effect of folate-binding proteins on bioavailability of folate from milk products" 16 : 307-310, 2005

      8 Campos-Giménez E, "The contribution of minor folates to the total vitamin B9 content of Infant formula and clinical nutrition products" 249 : 91-97, 2018

      9 Verwei M, "The binding of folic acid and 5-methyltetrahydrofolate to folate-binding proteins during gastric passage differs in a dynamic in vitro gastrointestinal model" 134 : 31-37, 2004

      10 Bourlieu C, "Specificity of infant digestive conditions: some clues for developing relevant in vitro models" 54 : 1427-1457, 2014

      11 Ford JE, "Some observations on the possible nutritional significance of vitamin B12- and folate binding proteins in milk" 31 : 243-257, 1974

      12 Tani M, "Some nutritional effects of folate binding protein in bovine milk on the bioavailability of folate to rats" 114 : 778-785, 1984

      13 Swiatlo N, "Relative folate bioavailability from diets containing human, bovine and goat milk" 120 : 172-177, 1990

      14 DiPalma J, "Lipase and pepsin activity in the gastric mucosa of infants, children, and adults" 101 : 116-121, 1991

      15 Svendsen IB, "Isolation and characterization of the folate-binding protein from cow’s milk" 44 : 89-99, 1979

      16 Salter D, "Influence of goat’s-milk folate-binding protein on transport of 5-methyltetrahydrofolate in neonatal-goat small intestinal brush-border-membrane vesicles" 59 : 409-507, 1988

      17 Tani M, "Influence of folate binding protein from bovine milk on the absorption of folate in gastrointestinal tract of rat" 757 : 274-281, 1983

      18 Papandreou D, "Homocysteine lowering with folic acid supplements in children: Effects on blood pressure" 61 : 11-17, 2010

      19 Eichholzer M, "Folic acid: a public-health challenge" 367 : 1352-1361, 2006

      20 Verwei M, "Folic acid and 5-methyltetrahydrofolate in fortified milk are bioaccessible as determined in a dynamic in vitro gastrointestinal model" 133 : 2377-2383, 2003

      21 Konings EJM, "Folate intake of the Dutch population according to newly established liquid chromatography data for foods" 73 : 765-776, 2001

      22 He H, "Folate intake and risk of bladder cancer: a meta-analysis of epidemiological studies" 65 : 286-292, 2014

      23 Rychlika M, "Folate contents of legumes determined by optimized enzyme treatment and stable isotope dilution assays" 20 : 411-419, 2007

      24 Wigertz K, "Folate and folate-binding protein content in dairy products" 64 : 239-252, 1997

      25 Gregory JF, "Fluorometric determination of folacin in biological materials using high performance liquid chromatography" 114 : 341-353, 1984

      26 Lee SJ, "Development of novel in vitro human digestion systems for screening the bioavailability and digestibility of foods" 22 : 113-121, 2016

      27 Colman N, "Detection of a milk factor that facilitates folate uptake by intestinal cells" 211 : 1427-1429, 1981

      28 European Commission, "Commission Directive 2006/141/EC of December 22, 2006 on infant formulae and follow-on formulae and amending Directive 1999/21/EC"

      29 Jong DRJ, "Bioavailability of folic acid from fortified pasteurised and UHT-treated milk in humans" 59 : 906-913, 2005

      30 Verwei M., "Bioavaibility of folate from fortified milk products" Wageningen University 2004

      31 Brandon EFA, "Bioaccessibility of vitamin A, vitamin C and folic acid from dietary supplements, fortified food and infant formula" 65 : 426-435, 2014

      32 Arkbåge K, "Bioaccessibility of folic acid and (6S)-5-methyltetrahydrofolate decreases after the addition of folate-binding protein to yogurt as studied in a dynamic in vitro gastrointestinal model" 133 : 3678-3683, 2003

      33 Nygren-Babol L, "Affinity and rate constants for interactions of bovine folate-binding protein and folate derivatives determined by optical biosensor technology. Effect of stereoselectivity" 53 : 473-478, 2005

      34 Minekus M, "A standardised static in vitro digestion method suitable for food—an international consensus" 5 : 1113-1124, 2014

      35 Sopade PA, "A rapid in vitro digestibility assay based on glucometry for investigating kinetics of starch digestion" 61 : 245-255, 2009

      36 Nguyen TP, "A comprehensive review on in vitro digestion of infant formula" 76 : 373-386, 2015

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      연월일 이력구분 이력상세 등재구분
      2023 평가예정 해외DB학술지평가 신청대상 (해외등재 학술지 평가)
      2020-01-01 평가 등재학술지 유지 (해외등재 학술지 평가) KCI등재
      2010-11-23 학회명변경 영문명 : Korean Society Of Food Science And Biotechnology -> Korean Society of Food Science and Technology KCI등재
      2010-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2008-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2006-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2004-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2001-07-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      1999-01-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 0.75 0.17 0.56
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.49 0.43 0.364 0.06
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