Prunus Davidiana, known as wild peach, has been used as a medicinal material against various inflammatory diseases since ancient times and belongs to the family Rosaceae. This study aimed to investigate the effect of wild peach extract (WPE) on inflam...
Prunus Davidiana, known as wild peach, has been used as a medicinal material against various inflammatory diseases since ancient times and belongs to the family Rosaceae. This study aimed to investigate the effect of wild peach extract (WPE) on inflammatory bowel diseases IBD at two different doses (10 and 100 mg/kg). Colitis was induced in mice (C57BL/6) by administering 2.0% Dextran sodium sulfate (DSS) in drinking water for 5 days. WPE treatment significantly improved the disease activity index, addressing symptoms such as body weight loss, bloody stool, stool consistency, and colon shortening. Furthermore, the increased levels of myeloperoxidase and pro-inflammatory cytokines (IL-6 and IL-22) with the development of colitis following DSS administration were significantly decreased by WPE. Histological analysis with Hematoxylin & Eosin staining of the colon tissue suggested that WPE significantly reduced colon damage.
Additionally, pro-inflammatory cytokine (IL-8) and reactive oxygen species levels were reduced in HT-29 cells. Based on these results, we suggest that P. davidiana can ameliorate DSS-induced colitis in a mouse model. Furthermore, we anticipate that P. davidiana could serve as an effective therapeutic candidate for the treatment of inflammatory bowel diseases.