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      Gait and tremor assessment for patients with Parkinson’s disease using wearable sensors

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      https://www.riss.kr/link?id=A107042041

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      다국어 초록 (Multilingual Abstract)

      Typically, subjects with Parkinson’s disease (PD) display instances of tremor at an early stage of the disease and later on develop gait impairments and postural instability. In this research, we have investigated the effect of using both gait and t...

      Typically, subjects with Parkinson’s disease (PD) display instances of tremor at an early stage of the disease and later on develop gait impairments and postural instability. In this research, we have investigated the effect of using both gait and tremor features for an early detection and monitoring of PD. Various features were extracted from the data collected from the wearable sensors and further analyzed using statistical analysis and machine learning techniques to find the most significant features that would best distinguish between the two groups: subjects with PD and healthy control subjects. The analysis of our results shows that the features of step distance, stance and swing phases, heel and normalized heel forces contributed more significantly to achieving a better classification between the two groups in comparison with other features. Moreover, the tremor analysis based on the frequency-domain characteristics of the signal including amplitude, power distribution, frequency dispersion, and median frequency was carried out to identify PD tremor from atypical Parkinsonism tremor.

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      참고문헌 (Reference)

      1 A. Beuter, "Using frequency domain characteristics to discriminate physiologic and Parkinsonian tremors" 16 (16): 484-494, 1999

      2 S.W. Smith, "The Scientist and Engineer’s Guide to Digital Signal Processing" California Technical Publishing 1999

      3 J.M. Hausdorff, "Rhythmic auditory stimulation modulates gait variability in Parkinson’s disease" 26 (26): 2369-2375, 2007

      4 G. Rigas, "Real-Time Quantification of Resting Tremor in the Parkinson’s Disease" 2009

      5 H. Dai, "Quantitative assessment of Parkinsonian tremor based on an inertial measurement unit" 15 (15): 25055-25071, 2015

      6 A. Salarian, "Quantification of tremor and bradykinesia in Parkinson’s disease using a novel ambulatory monitoring system" 54 (54): 313-322, 2007

      7 T. Heida, "Power spectral density analysis of physiological, rest and action tremor in Parkinson’s disease patients treated with deep brain stimulation" 10 (10): 2013

      8 R.O. Duda, "Pattern Classification" John Wiley & Sons 2001

      9 P. Nausieda, "Parkinson’s Disease: What You and Your Family Should Know" The National Parkinson Foundation Inc. 1999

      10 "Parkinson’s Disease Foundation"

      1 A. Beuter, "Using frequency domain characteristics to discriminate physiologic and Parkinsonian tremors" 16 (16): 484-494, 1999

      2 S.W. Smith, "The Scientist and Engineer’s Guide to Digital Signal Processing" California Technical Publishing 1999

      3 J.M. Hausdorff, "Rhythmic auditory stimulation modulates gait variability in Parkinson’s disease" 26 (26): 2369-2375, 2007

      4 G. Rigas, "Real-Time Quantification of Resting Tremor in the Parkinson’s Disease" 2009

      5 H. Dai, "Quantitative assessment of Parkinsonian tremor based on an inertial measurement unit" 15 (15): 25055-25071, 2015

      6 A. Salarian, "Quantification of tremor and bradykinesia in Parkinson’s disease using a novel ambulatory monitoring system" 54 (54): 313-322, 2007

      7 T. Heida, "Power spectral density analysis of physiological, rest and action tremor in Parkinson’s disease patients treated with deep brain stimulation" 10 (10): 2013

      8 R.O. Duda, "Pattern Classification" John Wiley & Sons 2001

      9 P. Nausieda, "Parkinson’s Disease: What You and Your Family Should Know" The National Parkinson Foundation Inc. 1999

      10 "Parkinson’s Disease Foundation"

      11 J.R. Hughes, "Parkinsonian abnormality of foot strike: A phenomenon of ageing and/or one responsive to levodopa therapy?" 29 : 179-186, 1990

      12 N.Md. Tahir, "Parkinson disease gait classification based on machine learning approach" 12 : 180-185, 2012

      13 "National Parkinson Foundation"

      14 S. Patel, "Monitoring motor fluctuations in patients with Parkinson’s disease using wearable sensors" 13 (13): 864-873, 2009

      15 "Minitab 17 Statistical Software" Minitab, Inc

      16 "MATLAB 8.6"

      17 R. Edwards, "Indexes for identification of abnormal tremor using computer tremor evaluation systems" 46 (46): 895-898, 1999

      18 S.H. Koozekanani, "Ground reaction forces during ambulation in Parkinsonism: Pilot study" 68 : 28-30, 1987

      19 J.M. Hausdorff, "Gait in Parkinson’s Disease"

      20 A. Salarian, "Gait assessment in Parkinson’s disease: Toward an ambulatory system for long-term monitoring" 51 (51): 1434-1443, 2004

      21 A. Muro-de-la-Herran, "Gait analysis methods: An overview of wearable and non-wearable systems, highlighting clinical applications" 14 : 3362-3394, 2014

      22 J. Perry, "Gait Analysis: Normal and Pathological Function" SLACK Incorporated 1992

      23 S. Frenkel-Toledo, "Effect of gait speed on gait rhythmicity in Parkinson’s disease: Variability of stride time and swing time respond differently" 2 (2): 2005

      24 A. Beuter, "Effect of Deep Brain Stimulation on Parkinsonian Tremor"

      25 C.L. Vaughan, "Dynamics of Human Gait" Kiboho Publishers 1999

      26 G. Yogev, "Dual tasking, gait rhythmicity, and Parkinson’s disease:Which aspects of gait are attention demanding?" 22 (22): 1248-1256, 2005

      27 J. Barth, "Biometric and mobile gait analysis for early diagnosis and therapy monitoring in Parkinson’s disease" 2011

      28 M. Mario, "Bioinformatic approaches used in modelling human tremor" 4 (4): 2009

      29 R. Okuno, "Analysis of spatial temporal plantar pressure pattern during gait in Parkinson’s disease" 1765-1768, 2008

      30 B.K. Scanlon, "An accelerometry-based study of lower and upper limb tremor in Parkinson’s disease" 20 : 827-830, 2013

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