<P><B>Abstract</B></P> <P>The applicability of confined crystallization is limited by the use of extra template materials unsuitable for oral dosage forms. In consideration of this limitation, mannitol was processed into...
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https://www.riss.kr/link?id=A107520107
2015
-
학술저널
1183-1190(8쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
<P><B>Abstract</B></P> <P>The applicability of confined crystallization is limited by the use of extra template materials unsuitable for oral dosage forms. In consideration of this limitation, mannitol was processed into...
<P><B>Abstract</B></P> <P>The applicability of confined crystallization is limited by the use of extra template materials unsuitable for oral dosage forms. In consideration of this limitation, mannitol was processed into a template with well controlled pores. This template was used for the subsequent confined crystallization of a model drug, resulting in drug/mannitol composite powders processable into the common operations of oral solid dosage forms. The confined crystallization produced a significant melting point depression, caused by a significant particle size reduction, but did not alter the crystal polymorphism. The <I>in vitro</I> release of drug was significantly improved by the confined crystallization.</P>
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