Mechanistic insights on burdock (Arctium lappa L.) extract effects on diabetes mellitus

다국어 초록 (Multilingual Abstract)

Diabetes mellitus (DM) type 2 is amongst the most common chronic diseases, being responsible for various problems in humans and contributing to increased mortality rates worldwide. Fructooligosaccharide, which can be produced from the roots of burdock (Arctium lappa L.), has been shown to have a wide range of pharmacological proprieties, including antiviral, anti-inflammatory, hypolipidemic, and antidiabetic effects. Moreover, burdock also contains chlorogenic acid, which has been used in traditional medicine as an antioxidant. Considering its natural origin and minimal toxicity, burdock fructooligosaccharides (BFO) has gained considerable attention from researchers owing its wide, efficient, and beneficial action against DM. Although the effectiveness of fructooligosaccharide and chlorogenic acid has been extensively discussed, limited information is available on the application of burdock for DM treatment. In this review, we discuss the beneficial contributions, and the recent in vitro and in vivo analytical findings on A. lappa extract as DM therapy.

참고문헌 (Reference)

1 Ortiz-Andrade, R. R, "α-Glucosidase inhibitory activity of the methanolic extract from Tournefortia hartwegiana: An anti-hyperglycemic agent" 109 : 48-53, 2007

2 Wang, R, "Variation of the content of chlorogenic acid derivatives among cultivars and market items of burdock ( Arctium lappa L.)" 48 : 857-862, 2001

3 Stefanov, S. M., "Valorization by compressed fluids of arctium lappa seeds and roots as a sustainable source of valuable compounds" 101821-, 2022

4 Yan, Y., "Use of chlorogenic acid against diabetes mellitus and its complications" 2020 : 2020

5 Juster-Switlyk, K., "Updates in diabetic peripheral neuropathy" 5 : 738-, 2016

6 Hussain, F, "Therapeutic attributes of stevia rebaudiana leaves in diabetic animal model plant sample collection and extract preparation" 12 : 1-7, 2021

7 Kumar, R, "Therapeutic promises of chlorogenic acid with special emphasis on its antiobesity property" 13 : 7-16, 2020

8 Lordan, S, "The α-amylase and α-glucosidase inhibitory effects of Irish seaweed extracts" 141 : 2170-2176, 2013

9 Tang, S. C. W, "The pathogenic role of the renal proximal tubular cell in diabetic nephropathy" 27 : 3049-3056, 2012

10 Benhaddou-Andaloussi, A., "The in vivo antidiabetic activity of nigella sativa is mediated through activation of the AMPK pathway and increased muscle Glut4 content" 2011 : 9-, 2011

11 Gao, Y, "The effects of hypoglycemia and weight loss of total lignans from Fructus Arctii in KKAy mice and its mechanisms of the activity" 32 : 631-642, 2018

12 Silver, A. A., "The effect of the ingestion of burdock root on normal and diabetic individuals" 49 : 1086-, 1956

13 Martina, S. J, "The difference in effect of Arabica coffee gayo beans and leaf (Coffea Arabica Gayo) extract on decreasing blood sugar levels in healthy mice" 7 : 3363-, 2019

14 Xu, Z, "The antidiabetic activity of total lignan from Fructus Arctii against alloxan-induced diabetes in mice and rats" 22 : 544-549, 2008

15 Mihaylova, M. M., "The AMPK signalling pathway coordinates cell growth, autophagy and metabolism" 13 : 1016-1023, 2011

16 복소현 ; 조승식 ; 배춘식 ; 박대훈 ; 박경목, "Safety of 8-weeks oral administration of Arctium lappa L." 한국실험동물학회 33 (33): 251-255, 2017

17 Liang, N, "Role of chlorogenic acids in controlling oxidative and inflammatory stress conditions" 8 : 16-, 2015

18 Moro, T. de M. A, "Retention of bioactive compounds and bifidogenic activity of burdock roots subjected to different processes" 27 : 100448-, 2022

19 Deng, Y. T, "Pu-erh tea polysaccharides decrease blood sugar by inhibition of α-glucosidase activity in vitro and in mice" 6 : 1539-1546, 2015

20 Moser, M., "Production and bioactivity of oligosaccharides from chicory roots" 55-75, 2014

21 Li, J, "Preparation of inulin-type fructooligosaccharides using fast protein liquid chromatography coupled with refractive index detection" 1308 : 52-57, 2013

22 Petkova, N, "Phytochemical composition and antimicrobial properties of burdock (Arctium lappa L.) roots extracts" 12 : 2826-2842, 2022

23 Barreto, N. M. B, "Organic black beans (Phaseolus vulgaris l.) from rio de janeiro state, brazil, present more phenolic compounds and better nutritional profile than nonorganic" 10 : 900-, 2021

24 Mussatto, S. I, "Non-digestible oligosaccharides: A review" 68 : 587-597, 2007

25 Sadeghi Ekbatan, S, "Molecular sciences chlorogenic acid and its microbial metabolites exert anti-proliferative effects, S-Phase cell-cycle arrest and apoptosis in human colon cancer caco-2 cells" 19 : 723-, 2018

26 Saravanakumar, K, "Metabolite profiling of methanolic extract of Gardenia jaminoides by LC-MS/MS and GC-MS and its anti-diabetic, and anti-oxidant activities" 14 : 102-, 2021

27 Mills, C. E, "In vitro colonic metabolism of coffee and chlorogenic acid results in selective changes in human faecal microbiota growth" 113 : 1220-1227, 2015

28 Rubel, I. A, "In vitro prebiotic activity of inulin-rich carbohydrates extracted from Jerusalem artichoke (Helianthus tuberosus L.) tubers at different storage times by Lactobacillus paracasei" 62 : 59-65, 2014

29 Ercan, P., "Inhibitory effects of chickpea and tribulus terrestris on lipase, α-amylase and α-glucosidase" 205 : 163-169, 2016

30 Kim, Y. M, "Inhibitory effect of pine extract on α-glucosidase activity and postprandial hyperglycemia" 21 : 756-761, 2005

31 Satoh, T, "Inhibitory effect of black tea and its combination with acarbose on small intestinal α-glucosidase activity" 161 : 147-155, 2015

32 Lin, L. Z, "Identification of hydroxycinnamoylquinic acids of arnica flowers and burdock roots using a standardized LC-DAD-ESI/MS profiling method" 56 : 10105-10114, 2008

33 Jaiswal, R, "Identification and characterization of five new classes of chlorogenic acids in burdock (Arctium lappa L.) roots by liquid chromatography/tandem mass spectrometry" 2 : 63-71, 2011

34 Bazool Farhood, H, "Hepatoprotective effects of chlorogenic acid under hyperglycemic conditions" 24 : 301-307, 2019

35 Saeedi, P, "Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th edition" 157 : 107843-, 2019

36 Sangeetha, P. T, "Fructooligosaccharide production using fructosyl transferase obtained from recycling culture of Aspergillus oryzae CFR 202" 40 : 1085-1088, 2005

37 Raskar, V, "Formulation of coffee bean extract (Chlorogenic Acid) solid lipid nanoparticles for lymphatic uptake on oral administration" 9 : 477-484, 2019

38 Mondal, S. C, "Extraction of phenolic compounds from burdock root waste using ultrasonication as a green technology" 2021

39 Xu, Z, "Evaluation of hypoglycemic activity of total lignans from Fructus Arctii in the spontaneously diabetic Goto-Kakizaki rats" 151 : 548-555, 2014

40 Tomac, I, "Evaluation of antioxidant activity of chlorogenic acids and coffee extracts by an electrochemical DNA-based biosensor" 325 : 126787-, 2020

41 Singh, A. K, "Evaluation of antidiabetic activity of dietary phenolic compound chlorogenic acid in streptozotocin induced diabetic rats: molecular docking, molecular dynamics, in silico toxicity, in vitro and in vivo studies" 134 : 104462-, 2021

42 Zhang, X, "Effects of acarbose on the gut microbiota of prediabetic patients: a randomized, double-blind, controlled crossover trial" 8 : 293-307, 2017

43 Herrera-Balandrano, D. D, "Effect of in vitro gastro-intestinal digestion on the phenolic composition and antioxidant capacity of burdock roots at different harvest time" 358 : 129897-, 2021

44 Tan, Y, "Comparison of α-amylase, α-glucosidase and lipase inhibitory activity of the phenolic substances in two black legumes of different genera" 214 : 259-268, 2017

45 Nwafor, E. O, "Chlorogenic acid: potential source of natural drugs for the therapeutics of fibrosis and cancer" 15 : 101294-, 2022

46 Lu, H, "Chlorogenic acid: A comprehensive review of the dietary sources, processing effects, bioavailability, beneficial properties, mechanisms of action, and future directions" 19 : 3130-3158, 2020

47 Ong, K. W, "Chlorogenic acid stimulates glucose transport in skeletal muscle via AMPK activation: a contributor to the beneficial effects of coffee on diabetes" 7 : e32718-, 2012

48 Yin, P, "Chlorogenic acid improves health in juvenile largemouth bass (Micropterus salmoides) fed high-fat diets: Involvement of lipid metabolism, antioxidant ability, inflammatory response, and intestinal integrity" 545 : 737169-, 2021

49 Gouthamchandra, K, "Chlorogenic acid complex (CGA7), standardized extract from green coffee beans exerts anticancer effects against cultured human colon cancer HCT-116 cells" 6 : 147-153, 2017

50 He, X, "Chlorogenic acid ameliorates obesity by preventing energy balance shift in high-fat diet induced obese mice" 101 : 631-637, 2021

51 Tousch, D, "Chemical analysis and antihyperglycemic activity of an original extract from burdock root (Arctium lappa)" 62 : 7738-7745, 2014

52 Kushwaha, P. P, "Characterization of phytochemicals and validation of antioxidant and anticancer activity in some Indian polyherbal ayurvedic products" 34 : 286-299, 2021

53 Yuan, P. chuan, "Burdock fructooligosaccharide as an α-glucosidase inhibitor and its antidiabetic effect on high-fat diet and streptozotocin-induced diabetic mice" 86 : 104703-, 2021

54 Ding, M, "Burdock fructooligosaccharide attenuates high glucose-induced apoptosis and oxidative stress injury in rrenal tubular epithelial cells" 12 : 784187-784187, 2021

55 Bento-Silva, A, "Broa, an ethnic maize bread, as a source of phenolic compounds" 10 : 672-, 2021

56 Plazas, M, "Breeding for chlorogenic acid content in eggplant: interest and prospects" 41 : 26-35, 2013

57 Kuo, D. H, "Body weight management effect of burdock (Arctium lappa L.) root is associated with the activation of AMP-activated protein kinase in human HepG2 cells" 134 : 1320-1326, 2012

58 Ferreres, F, "Bauhinia forficata link authenticity using flavonoids profile: relation with their biological properties" 134 : 894-904, 2012

59 Song, Y, "Associations of dietary flavonoids with risk of type 2 diabetes, and markers of insulin resistance and systemic inflammation in women: a prospective study and cross-sectional analysis" 24 : 376-384, 2013

60 Tsikas, D., "Assessment of lipid peroxidation by measuring malondialdehyde(MDA)and relatives in biological samples : analytical and biological challenges" 524 : 13-30, 2017

61 Annunziata, G., "Arctium lappa contributes to the management of type 2 diabetes mellitus by regulating glucose homeostasis and improving oxidative stress: A critical review of in vitro and in vivo animal-based studies" 33 : 2213-2220, 2019

62 Tang, X, "Arctigenin efficiently enhanced sedentary mice treadmill endurance" 6 : e24224-, 2011

63 Xu, Z, "Arctigenic acid, the key substance responsible for the hypoglycemic activity of Fructus Arctii" 22 : 128-137, 2015

64 Maruta, Y, "Antioxidative caffeoylquinic acid derivatives in the roots of burdock (Arctium lappa L.)" 43 : 2592-2595, 1995

65 Franco, R. R, "Antioxidant and anti-glycation capacities of some medicinal plants and their potential inhibitory against digestive enzymes related to type 2 diabetes mellitus" 215 : 140-146, 2018

66 Ahangarpour, A., "Antidiabetic, hypolipidemic and hepatoprotective effects of arctium lappa root’s hydro-alcoholic extract on nicotinamidestreptozotocin induced type 2 model of diabetes in male mice" 7 : 169-, 2017

67 Cao, J, "Antidiabetic effect of burdock (Arctium lappa L.) root ethanolic extract on streptozotocin-induced diabetic rats" 11 : 9079-9085, 2012

68 Boonphang, O., "Antidiabetic and renoprotective effects of coffea arabica pulp aqueous extract through preserving organic cation transport system mediated oxidative stress pathway in experimental type 2 diabetic rats" 26 : 1907-, 2021

69 Cui, J, "Anti-hyperglycaemic effects of burdock (Arctium lappa L.) leaf flavonoids through inhibiting α-amylase and α-glucosidase" 57 : 541-551, 2022

70 Dominguez, A. L, "An overview of the recent developments on fructooligosaccharide production and applications" 7 : 324-337, 2014

71 Patel, D. K, "An overview on antidiabetic medicinal plants having insulin mimetic property" 2 : 320-330, 2012

72 Upadhyay, R, "An outlook on chlorogenic acidsoccurrence, chemistry, technology, and biological activities" 53 : 968-984, 2013

73 Chan, Y. S, "A review of the pharmacological effects of arctium lappa (burdock)" 19 : 245-254, 2010

74 ADA(American Diabetes Association), "2. Classification and diagnosis of diabetes : Standards of medical care in diabetes-2021" 44 : S15-S33, 2021