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DBpiaThis study was designed to determine the hemolytic mechanism of antitumor agent tetraphosphine platinum (Ⅱ) complex (RC-1), which was synthesized recently. Erythrocytes treated with RC-1 showed concentration and time dependent lipid peroxydation, m...
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https://www.riss.kr/link?id=A45023257
- 저자
- 발행기관
- 학술지명
- 권호사항
-
발행연도
1993
-
작성언어
Korean
-
KDC
539.905
-
등재정보
SCOPUS,KCI등재
-
자료형태
학술저널
- 발행기관 URL
-
수록면
33-41(9쪽)
- 제공처
-
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부가정보
다국어 초록 (Multilingual Abstract)
This study was designed to determine the hemolytic mechanism of antitumor agent tetraphosphine platinum (Ⅱ) complex (RC-1), which was synthesized recently.
Erythrocytes treated with RC-1 showed concentration and time dependent lipid peroxydation, methemoglobin synthesis and hemolysis. And also treatment of radical scavengers showed the inhibitory effect of hemolysis and the decrease of malondialdehyde levels in RC-1 treated erythrocytes.
So, the mechanism of hemolysis was considered to be the generation of free radicals, methemoglobin synthesis and the lipid peroxidation of phospholipid which composed of erythrocyte membrane.
Erythrocytes treated with RC-1 showed concentration and time dependent lipid peroxydation, methemoglobin synthesis and hemolysis. And also treatment of radical scavengers showed the inhibitory effect of hemolysis and the decrease of malondialdehyde levels in RC-1 treated erythrocytes.
So, the mechanism of hemolysis was considered to be the generation of free radicals, methemoglobin synthesis and the lipid peroxidation of phospholipid which composed of erythrocyte membrane.
This study was designed to determine the hemolytic mechanism of antitumor agent tetraphosphine platinum (Ⅱ) complex (RC-1), which was synthesized recently.
Erythrocytes treated with RC-1 showed concentration and time dependent lipid peroxydation, methemoglobin synthesis and hemolysis. And also treatment of radical scavengers showed the inhibitory effect of hemolysis and the decrease of malondialdehyde levels in RC-1 treated erythrocytes.
So, the mechanism of hemolysis was considered to be the generation of free radicals, methemoglobin synthesis and the lipid peroxidation of phospholipid which composed of erythrocyte membrane.
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