고단백식이 Streptozotocin-당뇨병 백서의 신혈류동태와 신장 Kallikrein에 미치는 영향 = The Effects of Dietary Protein on Renal Hemodynamics and Renal Kallikrein in Streptozotocin-Diabetic Rats

다국어 초록 (Multilingual Abstract)

To evaluate the effects of dietary protein on renal hemodynamics and renal kallikrein in diabetes mellitus, glomerular filtration rate (GFR) and renal plasma flow (RPF), along with renal tissue levels and urinary excre-tion of kallikrein were measured in strepozotoisn (STZ)-diabetic rats fed 25％ ro 50％ protein diet for 4 weeks. GFR and RPF were significantly increased in 50％ protein fed STZ-diabetic rats compared to 25％ protein fed one. Urinary excretion of active kallikrein and pro-kallikrein were tended to increase persistantly in 50％ protein fed STZ-diabetic rats versus 25％ protein fed one but renal tissue level of active kallikrein was significantly higher in 25％ protein fed STZ-diabetic rats. Thess data suggest that high dietary protein can alter renal hemodynamics in STZ-diabetic rats, which may be associated with change in urinary excretion and activation rate of prokallikrein.