60세 이상 성인의 치매 관련 영향요인: 지역사회 기반 단면연구 = Factors Affecting Dementia Prevalence in People Aged 60 or Over: A Community based Cross-sectional Study

다국어 초록 (Multilingual Abstract)

Purpose: This study was done to examine the association between body mass index (BMI) and any type of clinical dementia. Methods:Participants were 60,321 people over 60 years of age enrolled in the Seoul Dementia Management Project in 2011. K-MMSE was usedto classify participants as having a cognitive impairment and the Clinical Dementia Rating or DSM-IV by psychiatrists or neurologists todetermine whether participants were in the dementia group or the non-dementia group. Descriptive statistics, chi-square test, and binarylogistic regression analysis were performed. Results: In the univariate analysis, age, education level, living with spouse, BMI, alcoholconsumption, and exercise were significantly associated with dementia. In multivariable analysis, increasing age was positively associatedwith dementia, and educational level was negatively associated with dementia. The exercise group had a lower prevalence of dementiathan the non-exercise group. The odds ratio of dementia in the over-weight and obese groups compared to the normal groupwas 0.85 (95% CI 0.60, 0.98) and 0.64 (95%CI 0.46, 0.75), respectively. Conclusion: Results indicate that dementia is negatively associatedwith increasing BMI in people aged 60 years or older, but a prospective cohort study is needed to elucidate the causal effect relationshipbetween BMI and dementia.

참고문헌 (Reference)

1 이윤경, "서울시 치매노인의 동반질환 및 건강습관" 한국간호과학회 41 (41): 411-422, 2011

2 Cho MJ, "The prevalence and risk factors of dementia in the Korean elderly" 156 : 43-48, 2009

3 Prince M, "The global prevalence of dementia: A systematic review and metaanalysis" 9 (9): 63-75, 2013

4 장원석, "The Relationship between Obesity and the High Probability of Dementia Based on the Body Mass Index and Waist Circumference" 대한가정의학회 33 (33): 17-24, 2012

5 Kang Y, "Seoul neuropsychological screening battery (SNSB) manual" Human Brain Research & Consulting Co 2003

6 Lee CN, "Risk factors of dementia" 13 (13): 129-132, 2012

7 Sharp ES, "Relationship between education and dementia: An updated systematic review" 25 (25): 289-304, 2011

8 Benito-Leon J, "Obesity and impaired cognitive functioning in the elderly: A population- based cross-sectional study (NEDICES)" 20 (20): 899-906, 2013

9 Xu WL, "Midlife overweight and obesity increase late-life dementia risk: A population- based twin study" 76 (76): 1568-1574, 2011

10 McDowell I, "Mapping the connections between education and dementia" 29 (29): 127-141, 2007

11 Gillette Guyonnet S, "IANA (International Academy on Nutrition and Aging) expert group: Weight loss and Alzheimer’s disease" 11 (11): 38-48, 2007

12 Forbes D, "Exercise programs for people with dementia" 12 : CD006489-, 2013

13 Choi SH, "Estimating the validity of the Korean version of expanded clinical dementia rating (CDR) scale" 19 (19): 585-591, 2001

14 Statistics Korea, "Elderly statistics 2010"

15 Lautenschlager NT, "Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: A randomized trial" 300 (300): 1027-1037, 2008

16 Lee JH, "Development of the Korean version of the consortium to establish a registry for Alzheimer's disease assessment packet (CERAD-K): Clinical and neuropsychological assessment batteries" 57 (57): P47-P53, 2002

17 Besser LM, "Body mass index, weight change, and clinical progression in mild cognitive impairment and Alzheimer disease" 28 (28): 36-43, 2014

18 Anstey KJ, "Body mass index in midlife and late-life as a risk factor for dementia: A meta-analysis of prospective studies" 12 (12): e426-e437, 2011

19 Ghaderpanahi M, "Association between late-life body mass index, waist circumference, and dementia: Kahrizak elderly study" 60 (60): 173-174, 2012

20 Albanese E, "Acosta D. Dementia severity and weight loss: A comparison across eight cohorts. The 10/66 study" 9 (9): 649-656, 2013

21 Johnson DK, "Accelerated weight loss may precede diagnosis in Alzheimer disease" 63 (63): 1312-1317, 2006

22 Gao S, "Accelerated weight loss and incident dementia in an elderly African-American cohort" 59 (59): 18-25, 2011

23 Kang Y, "A validity study on the Korean mini-mental state examination (K-MMSE) in dementia patients" 15 (15): 300-308, 1997

24 Ministry of Health and Welfare, "2012 survey of dementia prevalence"