<P>Species of the genus <I>Hypericum</I> contain a rich array of unusual polyketides, however, only a small proportion of the over 450 <I>Hypericum</I> species, other than the popular medicinal supplement St. John's Wort ...
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https://www.riss.kr/link?id=A107680295
2013
-
SCOPUS,SCIE
학술저널
354-370(17쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
<P>Species of the genus <I>Hypericum</I> contain a rich array of unusual polyketides, however, only a small proportion of the over 450 <I>Hypericum</I> species, other than the popular medicinal supplement St. John's Wort ...
<P>Species of the genus <I>Hypericum</I> contain a rich array of unusual polyketides, however, only a small proportion of the over 450 <I>Hypericum</I> species, other than the popular medicinal supplement St. John's Wort (<I>Hypericum perforatum</I>), have even been chemically characterized. <I>Hypericum gentianoides</I>, a small annual used medicinally by Cherokee Americans, contains bioactive acylphloroglucinols. Here, we identify acylphloroglucinol constituents of <I>H. gentianoides</I> and determine a potential pathway to their synthesis. Liquid chromatography/electrospray ionization‐mass spectrometry (LC/ESI‐MS) and HPLC‐UV indicate that the level of accumulation and profile of acylphloroglucinols in <I>H. gentianoides</I> vary little seasonally when grown in a greenhouse, but do vary with development and are highly dependent on the accession, highlighting the importance of the selection of plant material for study. We identify the chemical structures of the nine prevalent polyketides, based on LC/ESI‐MS and hybrid quadrupole orthogonal time‐of‐flight (Q‐TOF) mass spectrometry; these metabolites include one monomeric phlorisobutyrophenone (PIB) derivative and eight dimeric acylphloroglucinols. Q‐TOF spectrometry was used to identify eight additional PIB derivatives that were not detected by LC/ESI‐MS. These data lead us to propose that diacylphloroglucinols are synthesized via modification of PIB to yield diverse phloroglucinol and filicinic acids moieties, followed by dimerization of a phloroglucinol and a filicinic acid monomer to yield the observed complement of diacylphloroglucinols. The metabolomics data from <I>H. gentianoides</I> are accessible in plant metabolomics resource (PMR) (<url href='http://www.metnetdb.org/pmr'>http://www.metnetdb.org/pmr), a public metabolomics database with analysis software for plants and microbial organisms.</P>