Sarcopenia Is Associated with Cognitive Impairment and Depression in Elderly Korean Women

다국어 초록 (Multilingual Abstract)

<P><B>Background:</B></P><P>Sarcopenia has been implicated in the increased risk for cognitive impairment and depression associated with aging. In this cross-sectional study, we investigated the relationship of sarcopenia with cognitive impairment (MCI) and depression in a sample of 201 community-dwelling Korean women (mean age of 74.0±6.8 yr) between 2014 and 2015.</P><P><B>Methods:</B></P><P>The Korean version of mini-mental state examination and the center for epidemiologic studies depression scale was used to assess cognitive performance and depression, respectively. Grp strength was measured with a dynamometer. Demographics, body composition, education, alcohol consumption, and history of cardiovascular diseases were assessed as covariates.</P><P><B>Results:</B></P><P>Odds ratio (OR) and 95% confidence interval (95% CI) of MCI and depression were calculated according to sarcopenia status. Compared to non-sarcopenic, pre-sarcopenic and sarcopenic women had the ORs of 2.160 (95% CI of 0.840 – 5.554, <I>P</I>=0.030) and of 5.493 (95% CI of 1.854 – 16.270, <I>P</I>=0.002) for MCI. The OR of pre-sarcopenia for MCI remained significant (<I>P</I>=0.030) even after adjustments for age, body mass index (BMI), lean body mass, and education, while the OR of sarcopenia for MCI was no longer significant (<I>P</I>=0.084) when adjusted for the covariates. Compared to non-sarcopenic, pre-sarcopenic and sarcopenic women had the ORs of 3.750 (95% CI of 1.137 – 12.370, <I>P</I>=0.030) and of 4.687 (95% CI of 1.127–19.505, <I>P</I>=0.034) for depression. The ORs of pre-sarcopenia and sarcopenia for depression remained statistically significant (<I>P</I>=0.020 and <I>P</I>=0.042, respectively) even after adjusted for the covariates</P><P><B>Conclusion:</B></P><P>Sarcopenia was significantly associated with MCI and depression in otherwise healthy community dwelling elderly Korean women.</P>