감염 ; 당뇨병 발생 고위험군에서 체중 변화와 인슐린저항성의 연관성 = Endocrinology-metabolism ; Association between Change in Body Weight and Insulin Resistance in Individuals at Increased Risk of Diabetes

다국어 초록 (Multilingual Abstract)

Background/Aims: The present study aimed to investigate the associations between a change in body weight from 20 years of age to the present with insulin resistance and several parameters of metabolic syndrome in individuals at an increased risk of diabetes. Methods: From patients with a diagnosis related to an increased risk of diabetes who were examined at our endocrinology clinic from January 2012 to December 2014, the present study recruited 125 individuals between 30 and 64 years of age with hemoglobin A1c levels from 5.7 to 6.4%. The change in body weight of each patient from 20 years of age to the present was retrospectively determined, and the associations of this change with insulin resistance and several parameters of metabolic syndrome were analyzed. Results: The average gain in body weight after 20 years of age was 11.3 kg and there was no significance difference between the male and female patients. The proportion of overweight and obese patients at 20 years of age was 14%, but was 74% at the time of the visits to our endocrinology clinic. A change in body weight was significantly correlated with body mass index, insulin resistance, and waist circumference. Additionally, as the tertile of change in body weight increased, fasting insulin levels, insulin resistance, and the prevalence of abdominal obesity significantly increased. Conclusions: In the present study, an increase in body weight from 20 years of age to the present was correlated with insulin resistance and several parameters of metabolic syndrome in individuals at an increased risk of diabetes. (Korean J Med 2015;89:681-689)

참고문헌 (Reference)

1 Rimm EB, "Validity of self-reported waist and hip circumferences in men and women" 1 : 466-473, 1990

2 Japan Diabetes Society, "Treatment Guide for Diabetes 2010" Bunkodo 2010

3 Perry GS, "The validity of self-reports of past body weights by U.S. adults" 6 : 61-66, 1995

4 Tamakoshi K, "The accuracy of long-term recall of past body weight in Japanese adult men" 27 : 247-252, 2003

5 Lindström J, "The Finnish Diabetes Prevention Study (DPS): lifestyle intervention and 3-year results on diet and physical activity" 26 : 3230-3236, 2003

6 World Health Organization, Western Pacific Region, "The Asia-Pacific perspective: redefining obesity and its treatment"

7 "Summary of revisions for the 2010 Clinical Practice Recommendations" 33 (33): S3-, 2010

8 Knowler W, "Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin" 346 : 393-403, 2002

9 Tuomilehto J, "Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance" 344 : 1343-1350, 2001

10 Ford ES, "Pre-diabetes and the risk for cardiovascular disease: a systematic review of the evidence" 55 : 1310-1317, 2010

11 de Mutsert R, "Overweight in early adulthood, adult weight change, and risk of type 2 diabetes, cardiovascular diseases, and certain cancers in men: a cohort study" 179 : 1353-1365, 2014

12 Poirier P, "Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Fisease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism" 113 : 898-918, 2006

13 McAuley KA, "Intensive lifestyle changes are necessary to improve insulin sensitivity: a randomized controlled trial" 25 : 445-452, 2002

14 Nathan DM, "Impaired fasting glucose and glucose tolerance; implications for care" 30 : 753-759, 2007

15 Matthews DR, "Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man" 28 : 412-419, 1985

16 Hamman RF, "Effect of weight loss with lifestyle intervention on risk of diabetes" 29 : 2102-2107, 2006

17 Hamman RF, "Effect of weight Loss with lifestyle intervention on risk of diabetes" 29 : 2102-2107, 2006

18 이시훈, "Cutoff Values of Surrogate Measures of Insulin Resistance for Metabolic Syndrome in Korean Non-diabetic Adults" 대한의학회 21 (21): 695-700, 2006

19 McAdams MA, "Comparison of selfreported and measured BMI as correlates of disease markers in US adults" 15 : 188-196, 2007

20 Cho DH, "Clinical implications of prediabetes" 10 : 225-232, 2009

21 Wing RR, "Benefits of modest weight loss in improving cardiovascular risk factors in overweight and obese individuals with type 2 diabetes" 34 : 1481-1486, 2011

22 Reaven GM, "Banting lecture 1988. Role of insulin resistance in human disease" 37 : 1595-1607, 1988

23 Lee SY, "Appropriate waist circumference cutoff points for central obesity in Korean adults" 75 : 72-80, 2007

24 Dishion TJ, "A longitudinal analysis of friendship and substance use: bidirectional influence from adolescence to adulthood" 38 : 480-491, 2002