Analysis of Fundus Photography and Fluorescein Angiography in Nonarteritic Anterior Ischemic Optic Neuropathy and Optic Neuritis

다국어 초록 (Multilingual Abstract)

Purpose: We evaluated fundus and fluorescein angiography (FAG) findings and characteristics that can helpdistinguish nonarteritic anterior ischemic optic neuropathy (NAION) from optic neuritis (ON).
Methods: Twenty-three NAION patients and 17 ON with disc swelling patients were enrolled in this study. Weperformed fundus photography and FAG. The disc-swelling pattern, hyperemia grade, presence of splinterhemorrhages, cotton-wool spots, artery/vein ratio and degree of focal telangiectasia were investigated. TheFAG findings for each patient were compared with respect to the following features: the pattern of disc leakagein the early phase, arteriovenous (artery/vein) transit time (second), and the presence and pattern of the fillingdelay.
Results: Cotton-wool spots, focal telangiectasia, and venous congestion were more common in the affectedeyes of NAION patients. Upon FAG, 76.5% of the patients in the ON group exhibited normal choroidal circulation.
However, 56.5% of patients in the NAION group demonstrated abnormal filling defects, such as peripapillary,generalized, or watershed zone filling delays.
Conclusions: Fundus findings, including cotton-wool spots, focal telangiectasia, and venous congestion in theaffected eye, may be clues that can be used to diagnose NAION. In addition, choroidal insufficiencies on FAGcould be also helpful in differentiating NAION from ON.

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