A Single Dose Oral Toxicity Study of 1 : 1 Mixture of Panax notoginseng and Salvia miltiorrhiza (PASEL) in Sprague-Dawley Rats

다국어 초록 (Multilingual Abstract)

An extract of a 1 : 1 mixture of Panax notoginseng and Salvia miltiorrhiza (PASEL) has been used as a potential therapeutic of cardiovascular disease. As an initial step in evaluating the safety of PASEL, five Sprague-Dawley (SD) rats, at 6 weeks of age (female 104.5-116.7 g, male 138.8-151.3 g), were given a single oral dose (2,000 ㎎/㎏ body weight) of PASEL. Mortality, clinical signs, body weight changes and gross findings were recorded for 14 days following the administration. All treated rats survived and showed no adverse clinical signs. They showed body weight gain similar to that of control group and had no gross lesions at necropsy. These results indicate that median lethal dose (LD₅₀) of PASEL is higher than 2,000 mg/kg body weight in both sexes of SO rats.

목차 (Table of Contents)

• 재료 및 방법
• 결과 및 고찰
• 감사의 글
• 참고문헌

참고문헌 (Reference)

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