A Pictorial Review of I-123 MIBG Imaging of Neuroblastoma Utilizing a State-of-the-Art CZT SPECT/CT System

다국어 초록 (Multilingual Abstract)

The field of nuclear medicine is entering a new era of gamma-camera technology. Solid-state SPECT/CT systems will graduallyreplace the thallium-activated sodium-iodide NaI(Tl) systems. This digital technology allows drastic improvements inimage quality, radiotracer dose reduction, and procedure efficiency. This pictorial review presents our initial experience onan NM/CT 870 CZT system (GE Healthcare), equipped with dual-head cadmium zinc telluride (CZT) detectors, for I-123metaiodobenzylguanidine (MIBG) imaging in pediatric neuroblastoma. On planar imaging, CZT shows greater image qualitythan at conventional gamma-camera using the Infinia Hawkeye (GE Healthcare). Physiologic structures such as salivaryglands and myocardium show sharper borders with a more notable signal-to-noise ratio at CZT than conventional gammacamera. On SPECT imaging, the CZT scanner, combined with resolution recovery, demonstrates either comparable or greaterimage quality at 80% of the conventional gamma camera’s acquisition time. Due to the 2.46-mm detector pixel with fullyregistered collimator holes matching each pixel and direct conversion of photons into electrical signals, the CZT gammacamera system provides significant advantages in photon localization and energy resolution.