생분해성 Polycaprolactone의 합성 = Synthesis of Biodegradable Polycaprolactone

국문 초록 (Abstract)

다양한 에스터 중합용 금속 촉매중에서 ε- caprolactone을 중합하는데는 tin octoate가 가장 우수한 촉매활성을 나타내었다. 괴상중합에서 촉매농도가 증가하면 분자량이 감소하였고 반응온도가 높아지면 분자량과 수율이 증가하였으며 중합온도 180℃, 촉매 0.036㏖%, 중합시간 50분에서 분자량이 41,000인 polycaprolactone을 얻었다. 용액 중합에서도 유사한 경향을 보였다. Lipase가 용해되어 있는 pH 7.4인 완충용액에서 30일간 침지한 polycaprolactone은 분자량이 높을수록 분해가 느려지는 현상을 파단신율의 측정으로 알 수 있었다.

다국어 초록 (Multilingual Abstract)

The investigation of effective catalyst system for the polymerization of ε- caprolactone showed that tin octoate, among the various catalysts used for polycondensation, was exhibited as having the high catalyst activity. In bulk polymerization the molecular weight of resulting polycaprolactone was decreased with increasing the concentration of tin octcate, while yields and molecular weight were increased with increasing of reaction temperature. The polymerization of ε- caprolactone was carried out using 0.036㏖% catalyst at 140℃ for 50min to give polycaprolactone with a molecular weight of 41,000. The solution polymerization underwent in the same manner as the bulk polymerization. The prepared polycaprolactone was hydrolysed with lipase in pH. 7.4 buffer solution for 30days and its lose of elongation at breaking point determined revealed that polycaprolactone with high molecular weight was degradated slower than that with low molecular weight.