소아기 및 청소년기의 난소 종양에 대한 임상적 연구 = Ovarian neoplasms in Childhood and Adolescence : A Review of 159 Cases of Malignant and Benign Masses

다국어 초록 (Multilingual Abstract)

Objective : The purpose of this study was to review the clinical presentation, size, prevalence, tumor marker, treatment, outcomes and histopathologic findings of ovarian neoplasmas in childhood and adolescence.
Methods and Materials : Medical recordings of 155 patients aged 20 years or less with adnexal mass diagnosed at the Sanggye Paik Hospital from Jan. 1997 through Dec. 2006 were reviewed retrospectively
Results : The mean age of patients was 16.9±2.8 years. Abdominal pain is the most frequent symptom. The mean diameter of ovarian tumor was 12.9±8.5㎝. The number of benign ovarian tumors were 141 cases(88.7%) and the number of malignant or borderline ovarian tumors were 18 cases(11.3%). According to histopathological classification of malignant or borderline ovarian tumors, germ cell tumors were 11 cases(61.1%) and epithelial cell tumors were 7 cases(38.9%). The mean value of preoperative serum CA125 levels was 39.6±26.6 U/mL in the benign group, and 136.3±117.2 U/mL in the malignant group. According to FIGO classification of malignant or borderline ovarian tumors, most patients (17 cases) were stage Ⅰ and only one patient was stage Ⅲ. Most patients underwent unilateral salpingo-oophorectomy in an attempt for reproductive organ conservation, one case of stage Ⅲ disease was treated with hysterectomy, bilateral salpingo-oophorectomy and omentectomy. On follow up, all 18 patients survived between 5 months and 9 years 11 months after treatment.
Conclusion : The proportion of malignant or borderline neoplasms in childhood and adolescence group was 11.3%. Because of the potential for malignant ovarian neoplasm in this age group, the presence of ovarian neoplasms requires prompt evaluation and treatment.