전립선 비대증 환자에서 Alfuzosin, Doxazosin 단독요법 및 Finasteride를 포함한 병합요법의 효과비교 = The Effect of Alfuzosin, Doxazosin and Finasteride Combination Therapy in Patients with Benign Prostatic Hyperplasia

다국어 초록 (Multilingual Abstract)

Background: The aim of this study was to evaluate the efficacy of alpha-blocker monotherapy and alpha-blocker + 5-a】pha-reductase inhibitor combination therapy for the treatment of benign prostatic hyperplasia and the rate of surgery for acute urinary retention or resistance to medical therapy. Methods： From Jan. 200() to Jan. 2004，one hundred sixty five symptomatic BPH patients had taken alfuzosin only，doxazosin only, alfuzosin + finasteride, and doxazosin + finasteride. Eighteen patients had taken alfuzosin only，25 doxazosin only, 62 alfuzosin + finasteride, 60 doxazosin+finasteride. The mean follow-up time was 7.4土4.2 months, 10.5土6,4 months, 10.3 土5.6 months，and 10.6 土 6.8 months each. International prostatic symptom score (IPSS)，quality of life (QOL) index，PSA, and TRUS were checked at first visit. IPSS and QOL index monthly follow-up were clone. The response was assessed by measurement of IPSS and QOL index. The cases of acute urinary retention and surgery for resistance to medical therapy were included in this study. Result： The mean age of alfuzosin group is 62,2 土 8.2 years, doxazosin is 65.5 土 10.5 years, alfuzosin+finasteride is 66.7土9,4 years, and doxazosin+finasteride is 68,1 土 9.0 years. The mean PSA of patients is 1.45土(乂89ng/dl，1石3土LOOng/dl，1.63± 1.00ng/dl，and 1,83土 1.09ng/dl. The mean weight of prostate is 35.8土 18,lgm， 29.6土9.8gm，39.8土 18,lgm，and 35,5土 lO.Ogm, The change of IPSS after medication in four groups is 1Z5土7.7 to 8,5 土 6.2, 17.5 土4.8 to 9.8 土 4.0, 17,9 土 7.6 to 10.4 土 7.5, and 17.8 土 4,8 to 10J 土 8丄 The change of QOL index is 3.6土 1.1 to 2.3 土 1J，3.4土0.7 to 2.5土0.9, 3.6土 1,4 to 2.5土 1.3, and 3/7土 1,2 to 2.5土 1.3 (P<0,05). The rate of surgery for acute urinary retention or resistance to medical therapy is 11 J%, 8.3%，9.6%，and 6.6%. Conclusion: IPSS and QOL index are statistically improved in all of four groups after medical therapy but, no statistical difference was found between the efficacy of alpha-blocker monotherapy groups and those of alpha*blocker plus finasteride combination therapy groups. The comparison of rates of inevitable surgeries in each groups were also not different statistically. Monotherapy with Alpha-blocker is effective to improve low urinary tract symptom due to BPH, It will be necessary to make a long-term study about the efficacy of finasteride later.