목 적: 원발병소 불명암의 경부림프절 전이 환자에서 방사선치료의 결과를 분석하고자 후향적 연구를 실시하였다. 대상 및 방법: 1986년 1월부터 2005년 12월까지 원발병소 불명암의 경부림프...
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https://www.riss.kr/link?id=A82296983
2007
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경부림프절 전이 ; 원발병소 불명암 ; 방사선치료 ; 생존율 ; Neck node metastasis ; Unknown primary ; Radiotherapy ; Survival
510
KCI등재,SCOPUS
학술저널
219-226(8쪽)
0
0
상세조회0
다운로드국문 초록 (Abstract)
목 적: 원발병소 불명암의 경부림프절 전이 환자에서 방사선치료의 결과를 분석하고자 후향적 연구를 실시하였다. 대상 및 방법: 1986년 1월부터 2005년 12월까지 원발병소 불명암의 경부림프...
목 적: 원발병소 불명암의 경부림프절 전이 환자에서 방사선치료의 결과를 분석하고자 후향적 연구를 실시하였다.
대상 및 방법: 1986년 1월부터 2005년 12월까지 원발병소 불명암의 경부림프절 전이로 진단받고 근치적 목적으로
방사선치료 또는 수술 후 방사선치료를 실시한 환자 88명을 대상으로 본 연구를 시행하였다. 환자의 중앙연령은
59세(35∼74세)이고 남자 74명, 여자 14명이었다. 조직학적으로 편평상피암이 72명, 미분화세포암이 6명, 선암이
1명이었고 조직학적으로 분류할 수 없었던 환자가 9명이었다. N 병기는 N1 병기가 4명, N2a 병기가 10명, N2b 병
기 48명, N2c 병기가 8명, N3 병기가 18명이었다. 방사선치료만 시행 받은 환자는 10명, 동시병용 방사선-항암화
학요법을 받은 환자는 27명, 수술 및 수술 후 방사선치료는 35명, 수술 및 수술 후 동시병용 방사선-항암화학요법
은 16명의 환자에서 시행되었다. 상부 경부림프절과 잠재적 원발병소인 인후두에 조사된 총 방사선량은 50.4∼
79.6 Gy (중앙값, 59.4Gy)였고, 하부 경부림프절에 조사된 총 방사선량은 50∼59.4 Gy (중앙값 50Gy)였다. 추적관
찰기간은 1∼154개월(중앙값 32개월)이었다. 결 과: 완전관해를 얻은 환자는 57명(70.4%)이었고 부분환해는 8명(9.9%)의 환자에서 관찰되었다. 전체 환자의 5년 생존율은 43.9%였으며, 5년 무병생존율은 41.7%였다. 경부절제술 여부와 원발종양 발생 여부가 생존율에 영향을 미치는 예후인자이고, N 병기와 경부절제술 여부, 원발종양 발생여부가 무병생존율에 영향을 미치는 예후인자로 분석되었다. 결 론: 원발병소 불명암의 경부 림프절 전이 환자에서 근치적 수술과 방사선치료로 좋은 생존결과를 얻을 수 있으며, 양측 경부와 잠재적 원발병소를 포함한 광범위 방사선치료는 좋은 국소 제어율과 생존율을 기대할 수 있다. 그러나 광범위 방사선치료로 인한 부작용을 줄이기 위하여 방사선치료 범위에 대한 더 많은 연구가 필요하다.
다국어 초록 (Multilingual Abstract)
Purpose: The aim of this retrospective analysis was to analyze the results of radiotherapy administered to patients with neck node metastases from an unknown primary cancer, with or without neck dissection. Materials and Methods: From January 1986 t...
Purpose: The aim of this retrospective analysis was to analyze the results of radiotherapy administered to
patients with neck node metastases from an unknown primary cancer, with or without neck dissection.
Materials and Methods: From January 1986 to December 2005, 88 patients with neck node metastases from an
unknown primary cancer were treated with curative intent. The age of the patients ranged from 35 to 74 years
(median age, 59 years). There were 74 male and 14 female patients. Distribution of patients by N status was
as follows: N1, 4 patients; N2a, 10 patients; N2b, 48 patients; N2c, 8 patients; N3, 18 patients. Fifty-one
patients underwent neck dissection and 37 patients had only a biopsy (31 patients had fine-needle aspiration
and 6 patients had an excisional biopsy). All patients received radiotherapy. The follow-up time ranged from 1
to 154 months, with a median time of 32 months. Results: The overall survival (OS) and disease-free survival (DFS) rate at 5 years were 43.9% and 41.7%, respectively. The factors associated with the OS rate were neck dissection, and a subsequent primary tumor. Factors associated with the DFS rate were N stage, neck dissection, and a subsequent primary tumor. Neck failure was noted in 15 patients, distant metastases in 18 patients, and a subsequent primary tumor in 8 patients. Conclusion: With comprehensive radiotherapy given to the bilateral neck and the potential mucosal sites, good survival rates can be obtained in patients with neck node metastases from an unknown primary cancer. However, considering the side effects, a randomized trial is required to determine the optimal radiotherapy volume.
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2기(T3 또는 N1) 췌장암 환자들의 수술 후 방사선치료의 성적 및 고찰
후두암 및 폐암 세포주에서 Flavopiridol이 방사선에 의한 아포토시스에 미치는 영향
인간 유방암 세포 이식마우스에서 EGFR/HER2 복합 Tyrosine Kinase 억제제인 GW572016에 의한 방사선증진효과
학술지 이력
연월일 | 이력구분 | 이력상세 | 등재구분 |
---|---|---|---|
2024 | 평가예정 | 해외DB학술지평가 신청대상 (해외등재 학술지 평가) | |
2021-01-01 | 평가 | 등재학술지 선정 (해외등재 학술지 평가) | |
2020-12-01 | 평가 | 등재후보로 하락 (해외등재 학술지 평가) | |
2015-01-01 | 평가 | SCOPUS 등재 (기타) | |
2013-01-01 | 평가 | 등재후보 1차 FAIL (등재후보1차) | |
2012-04-01 | 평가 | 등재후보로 하락 (기타) | |
2012-01-01 | 평가 | 등재후보학술지 유지 (기타) | |
2011-12-30 | 학회명변경 | 영문명 : The Korean Society For Therapeutic Radiology And Oncology -> The Korean Society for Radiation Oncology | |
2011-08-22 | 학술지명변경 | 한글명 : 대한방사선종양학회지 -> Radiation oncology journal 외국어명 : The Journal of the Korean Society for Therapeutic Radiology and Oncology -> Radiation oncology journal | |
2009-01-01 | 평가 | 등재 1차 FAIL (등재유지) | |
2006-01-01 | 평가 | 등재학술지 선정 (등재후보2차) | |
2005-01-01 | 평가 | 등재후보 1차 PASS (등재후보1차) | |
2004-01-01 | 평가 | 등재후보학술지 유지 (등재후보1차) | |
2002-01-01 | 평가 | 등재후보학술지 선정 (신규평가) |
학술지 인용정보
기준연도 | WOS-KCI 통합IF(2년) | KCIF(2년) | KCIF(3년) |
---|---|---|---|
2016 | 0.31 | 0.31 | 0.25 |
KCIF(4년) | KCIF(5년) | 중심성지수(3년) | 즉시성지수 |
0.23 | 0.22 | 0.864 | 0.05 |