Increased levels of acute‐phase reactants and lymphopenia are predictors of disease severity in coronavirus disease 2019 (COVID‐19). This study aimed to investigate the role of apoptosis in the etiology of lymphopenia in patients with COVID‐19. ...
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https://www.riss.kr/link?id=O106361384
2021년
-
0146-6615
1096-9071
SCI;SCIE;SCOPUS
학술저널
2867-2874 [※수록면이 p5 이하이면, Review, Columns, Editor's Note, Abstract 등일 경우가 있습니다.]
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
Increased levels of acute‐phase reactants and lymphopenia are predictors of disease severity in coronavirus disease 2019 (COVID‐19). This study aimed to investigate the role of apoptosis in the etiology of lymphopenia in patients with COVID‐19. ...
Increased levels of acute‐phase reactants and lymphopenia are predictors of disease severity in coronavirus disease 2019 (COVID‐19). This study aimed to investigate the role of apoptosis in the etiology of lymphopenia in patients with COVID‐19. This multicentered, prospective, and case‐control study was conducted with polymerase chain reaction (+) severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) patients, and an age–gender‐matched control group. Samples were taken at the time of diagnosis and analyzed via flow cytometry within 24 h. The participants' demographic data and initial laboratory tests were also recorded. In total, 33 patients with COVID‐19 (mean age = 45.4 ± 17.2) and 25 controls (mean age = 43.4 ± 17.4) participated in the study. All patients were identified as having mild (16), moderate (5), or severe (12) disease severity. Both early and late apoptotic cells in B and T lymphocytes were increased in all patients with COVID‐19 (p < .05). Early apoptotic (EA) B and T lymphocytes were also higher in severe cases compared to mild cases (p = .026). There was no significant difference between lymphopenia and apoptosis in patients with COVID‐19. However, patients with lymphopenia (n = 14) and severe COVID‐19 (p = .013) had increased EA T lymphocytes. This study's results show that B and T lymphocytes' apoptosis increases in patients with COVID‐19. In addition, enhanced T lymphocyte apoptosis is associated with disease severity in lymphopenic patients with COVID‐19.
One of the causes of lymphopenia in COVID‐19 disease is lymphocyte apoptosis.
All lymphocyte subsets progress towards apoptosis with the disease severity.
In those with lymphopenia, T cells seem to progress to more apoptosis than B.
The IgG is markedly in a negative correlation with IgM in the lymphopenia group.
One of the causes of lymphopenia in COVID‐19 disease is lymphocyte apoptosis.
All lymphocyte subsets progress towards apoptosis with the disease severity.
In those with lymphopenia, T cells seem to progress to more apoptosis than B.
The IgG is markedly in a negative correlation with IgM in the lymphopenia group.
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