마그네슘에 의한 혈소판 응집의 억제에 관한 생화학적 기전 = Biochemical Mechanism of platelet aggregation inhibition induced by Magnesium.

다국어 초록 (Multilingual Abstract)

Magnesium ion, with high concentration(2mM), is associated with inhibition of platelet activity in several molecular moiety, but biochemical mechanism are not well known.
Since the property of a platelet agonist is to potentiate the response by another agonist in synergistic manner and reduce the response by antagonist, combination test between magnesium ion and the classical agonist was performed.
Epinephrine showed irreversible aggregation profile, and with magnesium ion, caused a little inhibitory effect on platelet aggregation: this inhibition was synergistically done by indomethacin and ASA: ADP only showed reversible aggregation profile, and combination with magnesium ion also showed inhibitory effects on platelet aggregation.
This result may suggest magnesium ion induce inhibition of platelet aggregation not by direct action as inhibitor on each agonist, but by certain mechanism of simultaneous action on several agonists.