<P>A new drug delivery device using cylindrical block copolymer nanochannels was successfully developed for controlled protein drug delivery applications. Depending on the hydrodynamic diameter of the protein drugs, the pore size in cylindrical ...
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https://www.riss.kr/link?id=A107575784
2010
-
SCOPUS,SCIE
학술저널
3817-3822(6쪽)
0
상세조회0
다운로드다국어 초록 (Multilingual Abstract)
<P>A new drug delivery device using cylindrical block copolymer nanochannels was successfully developed for controlled protein drug delivery applications. Depending on the hydrodynamic diameter of the protein drugs, the pore size in cylindrical ...
<P>A new drug delivery device using cylindrical block copolymer nanochannels was successfully developed for controlled protein drug delivery applications. Depending on the hydrodynamic diameter of the protein drugs, the pore size in cylindrical nanochannels could be controlled precisely down to 6 nm by Au deposition. Zero-order release of bovine serum albumin (BSA) and human growth hormone (hGH) by single-file diffusion, which has been observed for gas diffusion through zeolite pores, was realized up to 2 months without protein denaturation. Furthermore, a nearly constant <I>in vivo</I> release of hGH from the drug delivery nanodevice implanted to Sprague−Dawley (SD) rats was continued up to 3 weeks, demonstrating the feasibility for long-term controlled delivery of therapeutic protein drugs.</P><P><B>Graphic Abstract</B>
<IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2010/ancac3.2010.4.issue-7/nn100464u/production/images/medium/nn-2010-00464u_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn100464u'>ACS Electronic Supporting Info</A></P>
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